Protein Domain : IPR027059

Type:  Family Name:  Coatomer delta subunit
Description:  This entry represents the delta subunit of the coatomer complex, which is involved in the regulation of intracellular protein trafficking between the endoplasmic reticulum and the Golgi complex [].Proteins synthesised on the ribosome and processed in the endoplasmic reticulum are transported from the Golgi apparatus to the trans-Golgi network (TGN), and from there via small carrier vesicles to their final destination compartment. This traffic is bidirectional, to ensure that proteins required to form vesicles are recycled. Vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction of transfer []. While clathrin mediates endocytic protein transport, and transport from ER to Golgi, coatomers primarily mediate intra-Golgi transport, as well as the reverse Golgi to ER transport of dilysine-tagged proteins []. For example, the coatomer COP1 (coat protein complex 1) is responsible for reverse transport of recycled proteins from Golgi and pre-Golgi compartments back to the ER, while COPII buds vesicles from the ER to the Golgi []. Coatomers reversibly associate with Golgi (non-clathrin-coated) vesicles to mediate protein transport and for budding from Golgi membranes []. Activated small guanine triphosphatases (GTPases) attract coat proteins to specific membrane export sites, thereby linking coatomers to export cargos. As coat proteins polymerise, vesicles are formed and budded from membrane-bound organelles. Coatomer complexes also influence Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. In mammals, coatomer complexes can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Short Name:  Coatomer_dsu
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR10121:SF0

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0006890 IPR027059
GO:0030126 IPR027059

2 Ontology Annotations

GO Term Gene Name
GO:0006890 IPR027059
GO:0030126 IPR027059

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Carub.0008s0725.1.p PAC:39251374 Capsella rubella 580  
Zosma03g17550 PAC:50108677 Zostera marina 523  
Zosma03g18220 PAC:50106720 Zostera marina 523  
Ceric.05G018700.1.p PAC:50578152 Ceratopteris richardii 70  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            14690497
            15261670
            17041781
            11208122
            10469566