Protein Domain : IPR001132

Type:  Domain Name:  SMAD domain, Dwarfin-type
Description:  Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth []. The dwarfin family also includes the Drosophila protein MAD that is required for the function of decapentaplegic (DPP) and may play a role in DPP signalling. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Dpp []. This domain is also found in nuclear factor I (NF-I) or CCAAT box-binding transcription factor (CTF).This entry represents the SMAD (Mothers against decapentaplegic (MAD) homologue) (also called MH2 for MAD homology 2) domain found at the carboxy terminus of MAD related proteins such as Smads. This domain is separated from the MH1 domain by a non-conserved linker region. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers. Unlike MH1, MH2 does not bind DNA. The well-studied MH2 domain of Smad4 is composed of five alpha helices and three loops enclosing a beta sandwich. Smads are involved in the propagation of TGF-beta signals by direct association with the TGF-beta receptor kinase which phosphorylates the last two Ser of a conserved 'SSXS' motif located at the C terminus of MH2 [, , ]. Short Name:  SMAD_dom_Dwarfin-type
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF03166
PS51076
SM00524

1 Found In

DB identifier Type Name
IPR013790 Family Dwarfin

2 GO Annotations

GO Term Gene Name
GO:0006355 IPR001132
GO:0005622 IPR001132

2 Ontology Annotations

GO Term Gene Name
GO:0006355 IPR001132
GO:0005622 IPR001132

1 Parent Features

DB identifier Type Name
IPR017855 Domain SMAD domain-like

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Isati.0782s0002.1.p PAC:39302500 Isatis tinctoria 312  
Lesat.0165s0621.1.p PAC:39487317 Lepidium sativum 202  
Camar.1108s0004.1.p PAC:39599139 Cakile maritima 691  
Ibeam.9062s0001.1.p PAC:39785804 Iberis amara 377  
Spov3_chr5.02469 PAC:45128085 Spinacia oleracea 893  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            9230443
            8799132
            11532220