Protein Domain : IPR001799

Type:  Domain Name:  Ephrin receptor-binding domain
Description:  Ephrins are a family of proteins [] that are ligands of class V (EPH-related) receptor protein-tyrosine kinases. Initially identified as regulators of axon pathfinding and neuronal cell migration, the Eph receptors and their ephrin ligands are now known to have roles in many other cell-cell interactions, including those of vascular endothelial cells and specialised epithelia [].Ephrins are membrane-attached proteins of 205 to 340 residues. Attachment appears to be crucial for their normal function. Type-A ephrins are linked tothe membrane via a GPI linkage, while type-B ephrins are type-I membrane proteins.The globular ephrin receptor-binding domain (ephrin RBD) is a beta barrel composed of eight strands arranged in two sheets around a hydrophobic core. Interspersed between beta strands are two alpha helices andone 3(10) helix. The sheets are composed of mixed parallel and antiparallel beta strands arranged in a Greek key topology. Like other cell-surfaceproteins, ephrins contain disulfide bonds to enhance stability. Two buried disulfide bonds are present: one pair holds together beta strands C and F, andthe other pair anchors two small helices, E and I, at the top of the barrel [, ]. Short Name:  Ephrin_RBD
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0 Child Features

2 Contains

DB identifier Type Name
IPR008972 Domain Cupredoxin
IPR019765 Conserved_site Ephrin, conserved site

4 Cross Referencess

Identifier
PF00812
PR01347
PD002533
PS51551

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0016020 IPR001799

1 Ontology Annotations

GO Term Gene Name
GO:0016020 IPR001799

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Luann.0061s0104.1.p PAC:39386943 Lunaria annua 604  
Gobar.A13G098600.1.p A0A5J5T2R0 PAC:42265102 Gossypium barbadense 110  
Godar.A13G105600.1.p A0A5D2DYF5 PAC:42546162 Gossypium darwinii 103  
Nycol.K00622.1.p PAC:44516752 Nymphaea colorata 643  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11780069
            7838529
            11703926