Protein Domain : IPR013263

Type:  Domain Name:  DNA topoisomerase I, zinc ribbon-like, bacterial-type
Description:  DNA topoisomerases regulate the number of topological links between two DNA strands (i.e. change the number of superhelical turns) by catalysing transient single- or double-strand breaks, crossing the strands through one another, then resealing the breaks []. These enzymes have several functions: to remove DNA supercoils during transcription and DNA replication; for strand breakage during recombination; for chromosome condensation; and to disentangle intertwined DNA during mitosis [, ]. DNA topoisomerases are divided into two classes: type I enzymes (; topoisomerases I, III and V) break single-strand DNA, and type II enzymes (; topoisomerases II, IV and VI) break double-strand DNA [].Type I topoisomerases are ATP-independent enzymes (except for reverse gyrase), and can be subdivided according to their structure and reaction mechanisms: type IA (bacterial and archaeal topoisomerase I, topoisomerase III and reverse gyrase) and type IB (eukaryotic topoisomerase I and topoisomerase V). These enzymes are primarily responsible for relaxing positively and/or negatively supercoiled DNA, except for reverse gyrase, which can introduce positive supercoils into DNA. This entry represents the C-terminal zinc-ribbon-like domain found in bacterial topoisomerase I (type IA) enzymes. Escherichia colitopoisomerase I proteins contain five copies of a zinc-ribbon-like domain at their C terminus, two of which have lost their cysteine residues and are therefore probably not able to bind zinc []. This domain is still considered to be a member of the zinc-ribbon superfamily despite not being able to bind zinc. Short Name:  TopoI_Znr_bac
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0 Child Features

0 Contains

1 Cross References

Identifier
PF08272

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR013263
GO:0003918 IPR013263
GO:0006265 IPR013263
GO:0005694 IPR013263

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR013263
GO:0003918 IPR013263
GO:0006265 IPR013263
GO:0005694 IPR013263

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0023.1.p PAC:28856670 Arabidopsis halleri 855  
Brdisv1pangenome1007439m.p PAC:33655914 Brachypodium distachyon Pangenome 993  
Brdisv1BdTR11A1042349m.p PAC:35688503 Brachypodium distachyon BdTR11a 993  
Brdisv1BdTR11A1042797m.p PAC:35689713 Brachypodium distachyon BdTR11a 1013  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7770916
            11395412
            12596227
            12042765
            10873443