Protein Domain : IPR006359

Type:  Family Name:  Transcription elongation factor GreA
Description:  Bacterial GreA and GreB promote transcription elongation by stimulating an endogenous, endonucleolytic transcript cleavage activity of the RNA polymerase (RNAP) [], allowing RNA transcription to continue past template-encoded arresting sites. GreA and GreB are sequence homologues and have homologues inevery known bacterial genome. GreA and GreB stimulate transcript cleavage in different ways; GreA induces cleavage of 3'-RNA fragments 2-3 nt in length and can only preventthe formation of arrested complexes, whereas GreB induces cleavage of fragments up to 18 nt in length and can rescue pre-existing arrested complexes.The 2.2 Angstrom resolution crystal structure of Escherichia coliGreA comprises an N-terminal antiparallel alpha-helical coiled coil, and a C-terminal globular domain. While theC-terminal domain binds RNAP, the N-terminal coiled coil interacts with the transcript 3' end and is responsible for stimulating the transcriptcleavage reaction []. Functional differences between GreA and GreB correlate with the distribution of positively charged residues onone face of the N-terminal coiled coil.Because members of the family outside the Proteobacteria resemble GreA more closely than GreB, the GreB clade () forms a plausible outgroup and the remainder of the GreA/B family, included in this family, is designated GreA. In the Chlamydias and some spirochetes, the conserved region of these proteins is found as the C-terminal region of a much larger protein. Short Name:  Tscrpt_elong_fac_GreA
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0 Child Features

3 Contains

DB identifier Type Name
IPR022691 Domain Transcription elongation factor, GreA/GreB, N-terminal
IPR001437 Domain Transcription elongation factor, GreA/GreB, C-terminal
IPR018151 Conserved_site Transcription elongation factor, GreA/GreB, conserved site

1 Cross References

Identifier
TIGR01462

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0003677 IPR006359
GO:0032784 IPR006359

2 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR006359
GO:0032784 IPR006359

1 Parent Features

DB identifier Type Name
IPR028624 Family Transcription elongation factor GreA/GreB

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0099.1.p PAC:28856258 Arabidopsis halleri 341  
Brdisv1BdTR11A1044930m.p PAC:35690079 Brachypodium distachyon BdTR11a 1221  
Zosma07g03000 PAC:50101815 Zostera marina 165  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7854424
            12914698