Protein Domain : IPR010201

Type:  Family Name:  HflK
Description:  The accumulation of abnormal membrane proteins is something which must be avoided in order to maintain cell viability. In Escherichia coli, the membrane-bound, ATP-dependent protease FtsH plays a central role in the degradation of these abnormal proteins []. Known substrates of this protease include several lambda bacteriophage proteins, the heat-shock transcription factor sigma-32, and the unassembled form of the membrane protein SecY. While FtsH is active as a protease on its own, in vivo it forms a complex with a membrane-bound HflKC heterodimer. HflKC has a generally inhibitory effect on the protease activity of FtsH, though the mechanism of this inhibition is not known. The HflK and HflC polypeptides are paralogous, and often encoded by tandem genes within bacterial genomes.This entry represents the HflK subunit of the HflKC heterodimer. Short Name:  HflK
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PTHR10264:SF51
TIGR01933

0 Found In

1 GO Annotation

GO Term Gene Name
GO:0016021 IPR010201

1 Ontology Annotations

GO Term Gene Name
GO:0016021 IPR010201

1 Parent Features

DB identifier Type Name
IPR001972 Family Stomatin family

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0238.1.p PAC:28856562 Arabidopsis halleri 406  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15910274