Protein Domain : IPR005752

Type:  Family Name:  ATP-dependent DNA helicase Rep
Description:  Rep hexameric DNA helicase contain ATP-binding domains similar to those seen in monomeric helicases but which are arranged in a ring. There is compelling evidence to suggest that a single ssDNA molecule passes through the centre of the hexameric ring. Activity of the enzyme is based upon two separate but coupled activities, ssDNA translocation and duplex destabilisation, and is driven by energy derived from the continuous ATP-binding and hydrolysis events that take place in the active-site cleft. The resulting conformational changes that accompany these events underpin the coupling process and allow the helicase to translocate along the DNA, destabilising the duplex and separating the two strands in an active process []. Short Name:  Helicase_Rep
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0 Child Features

2 Contains

DB identifier Type Name
IPR014017 Domain UvrD-like DNA helicase, C-terminal
IPR014016 Domain UvrD-like Helicase, ATP-binding domain

2 Cross Referencess

Identifier
TIGR01074
MF_01920

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003677 IPR005752
GO:0004003 IPR005752
GO:0005524 IPR005752
GO:0006268 IPR005752

4 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR005752
GO:0004003 IPR005752
GO:0005524 IPR005752
GO:0006268 IPR005752

1 Parent Features

DB identifier Type Name
IPR000212 Family DNA helicase, UvrD/REP type

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0256.1.p PAC:28856537 Arabidopsis halleri 673  
Brdisv1pangenome1006849m.p PAC:33657586 Brachypodium distachyon Pangenome 628  
Brdisv1pangenome1011562m.p PAC:33620429 Brachypodium distachyon Pangenome 674  
Brdisv1BdTR8i1043823m.p PAC:34240989 Brachypodium distachyon BdTR8i 671  
Brdisv1BdTR11G1006507m.p PAC:34607983 Brachypodium distachyon BdTR11g 671  
Brdisv1BdTR11A1041639m.p PAC:35691047 Brachypodium distachyon BdTR11a 628  
Brdisv1BdTR11A1041278m.p PAC:35690378 Brachypodium distachyon BdTR11a 674  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11165517