Protein Domain : IPR007631

Type:  Domain Name:  RNA polymerase sigma factor 70, non-essential domain
Description:  The bacterial core RNA polymerase complex, which consists of five subunits, is sufficient for transcription elongation and termination but is unable to initiate transcription. Transcription initiation from promoter elements requires a sixth, dissociable subunit called a sigma factor, which reversibly associates with the core RNA polymerase complex to form a holoenzyme []. RNA polymerase recruits alternative sigma factors as a means of switching on specific regulons. Most bacteria express a multiplicity of sigma factors. Two of these factors, sigma-70 (gene rpoD), generally known as the major or primary sigma factor, and sigma-54 (gene rpoN or ntrA) direct the transcription of a wide variety of genes. The other sigma factors, known as alternative sigma factors, are required for the transcription of specific subsets of genes.With regard to sequence similarity, sigma factors can be grouped into two classes, the sigma-54 and sigma-70 families. Sequence alignments of the sigma70 family members reveal four conserved regions that can be further divided into subregions eg. sub-region 2.2, which may be involved in the binding of the sigma factor to the core RNA polymerase; and sub-region 4.2, which seems to harbor a DNA-binding 'helix-turn-helix' motif involved in binding the conserved -35 region of promoters recognised by the major sigma factors [, ]. This domain is found in the primary vegetative sigma factor. Its function is unclear, and it can be removed without apparent loss of function [, ]. Short Name:  RNA_pol_sigma_70_non-ess
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0 Child Features

0 Contains

1 Cross References

Identifier
PF04546

1 Found In

DB identifier Type Name
IPR013325 Domain RNA polymerase sigma factor, region 2

5 GO Annotations

GO Term Gene Name
GO:0003677 IPR007631
GO:0003700 IPR007631
GO:0016987 IPR007631
GO:0006352 IPR007631
GO:0006355 IPR007631

5 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR007631
GO:0003700 IPR007631
GO:0016987 IPR007631
GO:0006352 IPR007631
GO:0006355 IPR007631

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Araha.11756s0302.1.p PAC:28856318 Arabidopsis halleri 613  
Brdisv1BdTR11A1041581m.p PAC:35689232 Brachypodium distachyon BdTR11a 544  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            3052291
            1597408
            3092189
            11931761
            8858155