2 Proteins
DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
---|---|---|---|---|
Ibeam.8912s0001.1.p | PAC:39804696 | Iberis amara | 333 | |
HanXRQChr13g0407781 | A0A251STC6 | PAC:40316406 | Helianthus annuus | 215 |
Type: | Family | Name: | T-cell surface glycoprotein CD5 |
Description: | The egg peptide speract receptor is a transmembrane glycoprotein of about 500 amino acids []. Topologically, it comprises a large extracellulardomain of about 450 residues, followed by a transmembrane domain and a short cytoplasmic region of about 12 amino acids. The extracellulardomain contains 4 repeats of a well-conserved region, which spans 115 amino acids and contains 6 conserved cysteines. A similar domain is alsofound towards the C terminus of macrophage scavenger receptor type I [],a membrane glycoprotein implicated in the pathologic deposition of cholesterol in arterial walls during artherogenesis, and in the CD5glycoprotein, which acts as a receptor in regulating T-cell proliferation. The T1/Leu-1/CD5 glycoprotein is expressed at the surface membrane of all mature T cells. It has been implicated both in the proliferative response of activated T cells and in T-cell helper function []. Thecomplete amino-acid sequence of the T1 precursor has been deduced from cDNA clones. The protein contains a classical signal peptide; a 347-residue extracellular segment; a transmembrane region; and a 93-residue intra- cellular segment []. The extracellular region contains several cysteineresidues and comprises 2 speract receptor domains separated by a proline/ threonine-rich region []. CD5 has been shown to function as a receptor,delivering co-stimulatory signals to T-cells, interacting specifically with the cell-surface protein CD72 (Lyb-2 in mice) exclusive to B-cells []. | Short Name: | Tcell_CD5 |
DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
---|---|---|---|---|
Ibeam.8912s0001.1.p | PAC:39804696 | Iberis amara | 333 | |
HanXRQChr13g0407781 | A0A251STC6 | PAC:40316406 | Helianthus annuus | 215 |