Protein Domain : IPR025752

Type:  Family Name:  High pH protein family
Description:  This is a family of closely related high pH (HPH) proteins that are integral endoplasmic reticulum (ER) membrane proteins required for yeast survival under environmental stress conditions []. They interact with several subunits of the Sec63/Sec62 complex that mediates post-translational translocation of proteins into the ER []. Cells with mutant Hph1 and Hph2 proteins reveal phenotypes resembling those of mutants defective for vacuolar proton ATPase (V-ATPase) activity. The yeast V-ATPase is a multisubunit complex whose function, structure, and assembly have been well characterised. Cells with impaired V-ATPase activity fail to acidify the vacuole, cannot grow at alkaline pH, and are sensitive to high concentrations of extracellular calcium. Short Name:  HPH_family
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0 Child Features

0 Contains

1 Cross References

Identifier
PF13694

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0006950 IPR025752
GO:0005783 IPR025752

2 Ontology Annotations

GO Term Gene Name
GO:0006950 IPR025752
GO:0005783 IPR025752

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
HanXRQChr06g0164541 A0A251UEM5 PAC:40331072 Helianthus annuus 287  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            21097665
            15189990