| Type: | Domain | Name: | Mammalian uncoordinated homology 13, subgroup, domain 2 |
| Description: | Mammalian uncoordinated homology 13 (Munc13) proteins constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegansunc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana(Mouse-ear cress), C. elegans, Drosophila melanogaster(Fruit fly), Mus musculus(Mouse), Rattus norvegicus(Rat) and Homo sapiens(Human), some of which may function in a Munc13-like manner to regulate membrane trafficking. The MHD1 and MHD2 domains are predicted to be alpha-helical. | Short Name: | Munc13_subgr_dom-2 |
| DB identifier | Type | Name |
|---|---|---|
| IPR014772 | Domain | Mammalian uncoordinated homology 13, domain 2 |
| DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
|---|---|---|---|---|
| Bobra.0166s0117.1.p | PAC:40715513 | Botryococcus braunii |
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