| Type: | Domain | Name: | Formin, GTPase-binding domain |
| Description: | Diaphanous-related formins (Drfs) are a family of formin homology (FH) proteins that act as effectors of Rho small GTPases during growth factor-induced cytoskeletal remodelling, stress fibre formation, and cell division []. Drf proteins are characterised by a variety of shared domains: an N-terminal GTPase-binding domain (GBD), formin-homology domains FH1, FH2 () and FH3 (), and a C-terminal conserved Dia-autoregulatory domain (DAD) that binds the GBD.This entry represents the GBD, which is a bifunctional autoinhibitory domain that interacts with and is regulated by activated Rho family members. Mammalian Drf3 contains a CRIB-like motif within its GBD for binding to Cdc42, which is required for Cdc42 to activate and guide Drf3 towards the cell cortex where it remodels the actin skeleton []. | Short Name: | GTPase-bd |
| GO Term | Gene Name |
|---|---|
| GO:0003779 | IPR010473 |
| GO:0017048 | IPR010473 |
| GO:0030036 | IPR010473 |
| DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
|---|---|---|---|---|
| Bobra.0051s0048.1.p | PAC:40715062 | Botryococcus braunii |
1279
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