Protein Domain : IPR014402

Type:  Family Name:  Transcription factor, Skn7-like
Description:  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].This entry represents transcription factor, Skn7 type, including Skn7 from budding yeast and Prr1 from fission yeast [, , ]. Short Name:  Sig_transdc_resp-reg_Skn7
Paste the following link

1 Child Features

DB identifier Type Name
IPR027718 Family Transcription factor Skn7

1 Contains

DB identifier Type Name
IPR001789 Domain Signal transduction response regulator, receiver domain

1 Cross References

Identifier
PIRSF002595

0 Found In

6 GO Annotations

GO Term Gene Name
GO:0000156 IPR014402
GO:0003700 IPR014402
GO:0000160 IPR014402
GO:0006355 IPR014402
GO:0006950 IPR014402
GO:0005634 IPR014402

6 Ontology Annotations

GO Term Gene Name
GO:0000156 IPR014402
GO:0003700 IPR014402
GO:0000160 IPR014402
GO:0006355 IPR014402
GO:0006950 IPR014402
GO:0005634 IPR014402

1 Parent Features

DB identifier Type Name
IPR027725 Family Heat shock transcription factor family

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cocit.L4278.1.p PAC:41072220 Corymbia citriodora 597  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12372152
            10966457
            16176121
            18076326
            11934609
            11489844
            7957083
            10888672
            10348908