Protein Domain : IPR004090

Type:  Family Name:  Chemotaxis methyl-accepting receptor
Description:  Methyl-accepting chemotaxis proteins (MCPs) are a family of bacterial receptors that mediate chemotaxis to diverse signals, responding to changes in the concentration of attractants and repellents in the environment by altering swimming behaviour []. Environmental diversity gives rise to diversity in bacterial signalling receptors, and consequently there are many genes encoding MCPs []. For example, there are four well-characterised MCPs found in Escherichia coli: Tar (taxis towards aspartate and maltose, away from nickel and cobalt), Tsr (taxis towards serine, away from leucine, indole and weak acids), Trg (taxis towards galactose and ribose) and Tap (taxis towards dipeptides). MCPs share similar topology and signalling mechanisms. MCPs either bind ligands directly or interact with ligand-binding proteins, transducing the signal to downstream signalling proteins in the cytoplasm. MCPs undergo two covalent modifications: deamidation and reversible methylation at a number of glutamate residues. Attractants increase the level of methylation, while repellents decrease it. The methyl groups are added by the methyl-transferase cheR and are removed by the methylesterase cheB. Most MCPs are homodimers that contain the following organisation: an N-terminal signal sequence that acts as a transmembrane domain in the mature protein; a poorly-conserved periplasmic receptor (ligand-binding) domain; a second transmembrane domain; and a highly-conserved C-terminal cytoplasmic domain that interacts with downstream signalling components. The C-terminal domain contains the glycosylated glutamate residues. This entry contains several methyl-accepting chemotaxis proteins, as well as related prokaryotic signalling receptors. All these proteins are composed of the same structural domains as found in classical MCPs. Short Name:  Chemotax_Me-accpt_rcpt
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0 Child Features

3 Contains

DB identifier Type Name
IPR003122 Domain Chemotaxis methyl-accepting receptor, ligand-binding
IPR004089 Domain Methyl-accepting chemotaxis protein (MCP) signalling domain
IPR004091 PTM Chemotaxis methyl-accepting receptor, methyl-accepting site

1 Cross References

Identifier
PR00260

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0004871 IPR004090
GO:0006935 IPR004090
GO:0007165 IPR004090
GO:0016020 IPR004090

4 Ontology Annotations

GO Term Gene Name
GO:0004871 IPR004090
GO:0006935 IPR004090
GO:0007165 IPR004090
GO:0016020 IPR004090

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30821.m000031 B9TDA0 PAC:16824634 Ricinus communis 242  
31427.m000026 B9TG46 PAC:16825019 Ricinus communis 269  
27509.m000031 B9TBQ5 PAC:16798560 Ricinus communis 319  
29426.m000031 PAC:16802832 Ricinus communis 448  
Pp3s30_490V3.1.p PAC:32948505 Physcomitrium patens 589  
Zosma07g03210 PAC:50101754 Zostera marina 174  
Zosma07g03160 PAC:50102164 Zostera marina 609  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16359703
            17299051