Protein Domain : IPR003997

Type:  Family Name:  RTX secretion protein D, Gram-negative bacteria
Description:  Secretion of virulence factors in Gram-negative bacteria involves transportation of the protein across two membranes to reach the cell exterior []. Four principal exotoxin secretion systems have been described. In the type II and IV secretion systems, toxins are first exported to the periplasm by way of a cleaved N-terminal signal sequence; a second set of proteins is used for extracellular transport (type II), or the C terminus of the exotoxin itself is used (type IV). Type III secretion involves at least 20 molecules that assemble into a needle; effector proteins are then translocated through this without need of a signal sequence. In the Type I system, a complete channel is formed through both membranes, and the secretion signal is carried on the C terminus of the exotoxin. The RTX (repeats in toxin) family of cytolytic toxins belong to the Type I secretion system, and are important virulence factors in Gram-negative bacteria. As well as the C-terminal signal sequence, several glycine-richrepeats are also found. These are essential for binding calcium, and are critical for the biological activity of the secreted toxins []. All RTX toxin operons exist in the order rtxCABD, RtxA protein being the structuralcomponent of the exotoxin, both RtxB and D being required for its export from the bacterial cell; RtxC is an acyl-carrier-protein-dependent acyl- modification enzyme, required to convert RtxA to its active form [].Escherichia colihaemolysin (HlyA) is often quoted as the model for RTX toxins. Recent work on its relative rtxC gene product HlyC [] has revealed that it provides the acylation aspect for post-translational modification of two internal lysine residues in the HlyA protein. HlyD provides a cytoplasmic transport moiety for HlyA, and is situated in both the cytoplasm and periplasm, having a single transmembrane segment []. Short Name:  Rtx_secretion_protD_GmN_bac
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1 Child Features

DB identifier Type Name
IPR010129 Family Type I secretion membrane fusion protein, HlyD

1 Contains

DB identifier Type Name
IPR006144 Conserved_site Secretion protein HlyD, conserved site

1 Cross References

Identifier
PR01490

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0009306 IPR003997
GO:0016020 IPR003997

2 Ontology Annotations

GO Term Gene Name
GO:0009306 IPR003997
GO:0016020 IPR003997

1 Parent Features

DB identifier Type Name
IPR006143 Family RND efflux pump, membrane fusion protein

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30333.m000035 B9TG05 PAC:16824350 Ricinus communis 291  
27739.m000027 B9TCF4 PAC:16799044 Ricinus communis 305  
Medtr1882s0010.1 A0A072TNL8 PAC:31084677 Medicago truncatula 394  
Spipo0G0161500 PAC:31509048 Spirodela polyrhiza 375  
Brdisv1BdTR11A1049643m.p PAC:35693247 Brachypodium distachyon BdTR11a 302  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1558765
            8800842
            10470043
            9521785
            1495479