| Type: | Domain | Name: | ASX homology domain |
| Description: | This entry represents a conserved alpha helical domain with a characteristic LXXLL motif found in Asx and homologues [, ]. The LXXLL motif is detected in diverse transcription factors, coactivators and co-repressors and is implicated in mediating interactions between them []. The Asx homology (ASXH) domain is found in animals, fungi and plants [] and is predicted to play a role in mediating contact between transcription factors and chromatin-associated complexes. In Drosophila Asx and Human ASXL1, the ASXH domain is predicted to mediate interactions with the Calypso and BAP1 deubiquitinases (DUBs) which further belong to the UCHL5/UCH37 clade of DUBs []. | Short Name: | ASXH |
