Protein Domain : IPR027463

Type:  Domain Name:  Multidrug efflux transporter AcrB TolC docking domain, DN/DC subdomains
Description:  The multidrug exporter AcrB is the inner membrane component of the AcrAB-TolC drug efflux system in Escherichia coli, responsible for the resistance of this organism to a wide range of drugs. AcrB exists as a homotrimer, with each subunit containing 12 transmembrane (TM) helices and a large periplasmic part formed by two loops between TM helices 1 and 2 and TM helices 7 and 8. The trimer consists of three prominent domains, the TM domain, the adjacent pore domain and the TolC docking domain []. This entry represents two subdomains, known as DN and DC, found in the TolC docking domain of multidrug resistance proteins like AcrB []. Short Name:  AcrB_DN_DC_subdom
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
G3DSA:3.30.2090.10
SSF82714

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

77 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30613.m000020 B9TDA4 PAC:16824509 Ricinus communis 358  
31376.m000014 B9TDY8 PAC:16824984 Ricinus communis 531  
32338.m000015 B9TFL0 PAC:16825392 Ricinus communis 400  
36027.m000015 PAC:16826845 Ricinus communis 417  
47498.m000013 B9TQD9 PAC:16828000 Ricinus communis 246  
58658.m000013 B9TNW2 PAC:16829166 Ricinus communis 282  
28854.m000051 B9T9P2 PAC:16801861 Ricinus communis 539  
28243.m000039 B9TA43 PAC:16800432 Ricinus communis 927  
Cagra.2369s0001.1.p PAC:28904052 Capsella grandiflora 148  
Glyma.12G220200.1.p A0A0R0HKZ6 PAC:30548248 Glycine max 276  
SapurV1A.0295s0470.1.p PAC:31408844 Salix purpurea 1040  
Spipo24G0027200 PAC:31517684 Spirodela polyrhiza 172  
Eucgr.C00799.1.p A0A059CLY0 PAC:32038585 Eucalyptus grandis 729  
GSMUA_Achr1P14490_001 PAC:32314292 Musa acuminata 212  
Pp3c15_21310V3.1.p A0A2K1JDY4 PAC:32927732 Physcomitrium patens 589  
Pp3c15_21310V3.3.p A0A2K1JDY4 PAC:32927734 Physcomitrium patens 589  
Pp3c15_21310V3.2.p A0A2K1JDY4 PAC:32927733 Physcomitrium patens 589  
Aqcoe2G334400.1.p A0A2G5CHV6 PAC:33060588 Aquilegia coerulea 460  
Brdisv1pangenome1006527m.p PAC:33658590 Brachypodium distachyon Pangenome 394  
Brdisv1BdTR11A1043736m.p PAC:35694218 Brachypodium distachyon BdTR11a 592  
Brdisv1BdTR11A1044516m.p PAC:35691139 Brachypodium distachyon BdTR11a 1167  
Brdisv1BdTR11A1041356m.p PAC:35689447 Brachypodium distachyon BdTR11a 394  
Brdisv1BdTR11A1037379m.p PAC:35687141 Brachypodium distachyon BdTR11a 552  
Phvul.011G048900.1.p V7AE74 PAC:37154729 Phaseolus vulgaris 260  
Bol028966 PAC:37369718 Brassica oleracea capitata 199  
Pavir.8KG254400.1.p PAC:37600873 Panicum virgatum 1990  
Pavir.8NG103000.1.p PAC:37626555 Panicum virgatum 1762  
Oeu037846.2 PAC:37729419 Olea europaea 589  
Oeu001978.1 PAC:37701724 Olea europaea 204  
Oeu052530.1 PAC:37703186 Olea europaea 60  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17194213
            21905116