Protein Domain : IPR000673

Type:  Domain Name:  Signal transduction response regulator, chemotaxis, protein-glutamate methylesterase
Description:  Two-component signal transduction systems enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions []. Some bacteria can contain up to as many as 200 two-component systems that need tight regulation to prevent unwanted cross-talk []. These pathways have been adapted to response to a wide variety of stimuli, including nutrients, cellular redox state, changes in osmolarity, quorum signals, antibiotics, and more []. Two-component systems are comprised of a sensor histidine kinase (HK) and its cognate response regulator (RR) []. The HK catalyses its own auto-phosphorylation followed by the transfer of the phosphoryl group to the receiver domain on RR; phosphorylation of the RR usually activates an attached output domain, which can then effect changes in cellular physiology, often by regulating gene expression. Some HK are bifunctional, catalysing both the phosphorylation and dephosphorylation of their cognate RR. The input stimuli can regulate either the kinase or phosphatase activity of the bifunctional HK.A variant of the two-component system is the phospho-relay system. Here a hybrid HK auto-phosphorylates and then transfers the phosphoryl group to an internal receiver domain, rather than to a separate RR protein. The phosphoryl group is then shuttled to histidine phosphotransferase (HPT) and subsequently to a terminal RR, which can evoke the desired response [, ].This entry represents the signal transduction response regulator CheB involved in chemotaxis. CheB methylesterase is responsible for removing the methyl group from the gamma-glutamyl methyl ester residues in the methyl-accepting chemotaxis proteins (MCP). The enzyme catalyses the reaction: protein L-glutamate O-methyl ester and water is converted to protein L-glutamate and methanol. CheB is regulated through phosphorylation by CheA. The N-terminal region of the protein is similar to that of other regulatory components of sensory transduction systems. The Myxococcus xanthusFrzG protein also belongs to this family, and is required for the normal aggregation of cells during fruiting body formation. Short Name:  Sig_transdc_resp-reg_Me-estase

0 Child Features

0 Contains

4 Cross Referencess

Identifier
PF01339
PS50122
G3DSA:3.40.50.180
SSF52738

3 Found Ins

DB identifier Type Name
IPR012071 Family Chemotaxis glutamate methyltransferase
IPR008248 Family Signal transduction response regulator, chemotaxis, CheB
IPR011247 Family Chemotaxis protein-glutamate methylesterase

5 GO Annotations

GO Term Gene Name
GO:0000156 IPR000673
GO:0008984 IPR000673
GO:0000160 IPR000673
GO:0006935 IPR000673
GO:0005737 IPR000673

5 Ontology Annotations

GO Term Gene Name
GO:0000156 IPR000673
GO:0008984 IPR000673
GO:0000160 IPR000673
GO:0006935 IPR000673
GO:0005737 IPR000673

0 Parent Features

41 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
28356.m000072 B9T9U0 PAC:16800746 Ricinus communis 1204  
28708.m000187 B9T494 PAC:16801577 Ricinus communis 237  
Cucsa.184860.3 PAC:16967621 Cucumis sativus 1058  
Cagra.0159s0004.1.p PAC:28904213 Capsella grandiflora 259  
Glyma.13G301600.1.p C6SVY8 PAC:30500554 Glycine max 90  
Traes_7BL_87D6C1CF9.6 PAC:32003628 Triticum aestivum 465  
Oropetium_20150105_04363A PAC:36012547 Oropetium thomaeum 96  
Solyc07g054760.1.1 PAC:36160453 Solanum lycopersicum 83  
Solyc07g054800.1.1 PAC:36160094 Solanum lycopersicum 83  
Podel.10G188400.1.p PAC:37338421 Populus deltoides WV94 877  
PGSC0003DMP400032045 PAC:37432767 Solanum tuberosum 83  
PGSC0003DMP400032025 PAC:37433199 Solanum tuberosum 83  
Oeu042512.1 PAC:37701852 Olea europaea 230  
evm.model.Scaffold_315.875 PAC:37902334 Coffea arabica 464  
evm.model.Scaffold_624.197 PAC:37844270 Coffea arabica 464  
Sobic.009G255400.2.p A0A1Z5R461 PAC:37920756 Sorghum bicolor 408  
AH019290-RA PAC:38163308 Amaranthus hypochondriacus 554  
MisinT248800.1.p PAC:40468224 Miscanthus sinensis 255  
Thint.13G0415000.1.p PAC:40830672 Thinopyrum intermedium 451  
Thint.20G0233400.1.p PAC:40909007 Thinopyrum intermedium 1808  
Thint.V1625700.1.p PAC:40756265 Thinopyrum intermedium 120  
Thint.10G0125700.1.p PAC:40752625 Thinopyrum intermedium 154  
Glyma.13G301600.1.p C6SVY8 PAC:41141044 Glycine max 90  
GlysoPI483463.13G253000.1.p A0A445IBZ1 PAC:41192898 Glycine soja 90  
GlymaLee.13G259700.1.p C6SVY8 PAC:41251193 Glycine max Lee 90  
Solyc07g054760.1.1 PAC:41490860 Solanum lycopersicum 83  
Solyc07g054800.1.1 PAC:41489925 Solanum lycopersicum 83  
Pavir.4NG028681.1.p PAC:41635885 Panicum virgatum 815  
Gomus.D04G198900.1.p A0A5D2VFY2 PAC:42123364 Gossypium mustelinum 110  
Gotom.D04G210700.1.p A0A5D2LGD7 PAC:42239952 Gossypium tomentosum 110  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12372152
            10966457
            16176121
            18076326
            11934609
            11489844