Protein Domain : IPR011268

Type:  Family Name:  Purine nucleoside phosphorylase
Description:  This entry consists of three clades of purine phosphorylases based on a neighbour-joining tree using the MTAP family as an out group. The highest-branching clade () consists of a group of sequences from both Gram-positive and Gram-negative bacteria which have been shown to act as purine nucleotide phosphorylases but whose physiological substrate and role in vivo remain unknown [].Of the two remaining clades, one is xanthosine phosphorylase (XAPA, ); it is limited to certain gammaproteobacteria and constitutes a special purine phosphorylase found in a specialised operon for xanthosine catabolism []. The enzyme also acts on the same purines (inosine and guanosine) as the other characterised members of this subfamily, but is only induced when xanthosine must be degraded. The remaining and largest clade consists of purine nucleotide phosphorylases (PNPH, ) from metazoa [] and bacteria [] which act primarily on guanosine and inosine, and do not act on adenosine. Sequences from Clostridium and Thermotoga fall between these last two clades and are uncharacterised with respect to substrate range. Short Name:  Purine_phosphorylase
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3 Child Features

DB identifier Type Name
IPR010943 Family Xanthosine phosphorylase
IPR011270 Family Purine nucleoside phosphorylase I, inosine/guanosine-specific
IPR011269 Family Putative purine nucleotide phosphorylase

1 Contains

DB identifier Type Name
IPR018099 Conserved_site Purine phosphorylase, family 2, conserved site

3 Cross Referencess

Identifier
PTHR11904:SF9
PIRSF000477
TIGR01697

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0004731 IPR011268
GO:0006139 IPR011268

2 Ontology Annotations

GO Term Gene Name
GO:0004731 IPR011268
GO:0006139 IPR011268

1 Parent Features

DB identifier Type Name
IPR001369 Family PNP/MTAP phosphorylase

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Brdisv1pangenome1003411m.p PAC:33619627 Brachypodium distachyon Pangenome 274  
Brdisv1BdTR11A1024686m.p PAC:35653556 Brachypodium distachyon BdTR11a 274  
Cz11g08200.t1 PAC:38237466 Chromochloris zofingiensis 360  
28751.m000026 B9TC98 PAC:16801645 Ricinus communis 201  
28751.m000026 B9TC98 PAC:16801645 Ricinus communis 201  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2104852
            10537218
            10600382
            15808857