Protein Domain : IPR007492

Type:  Domain Name:  LytTR DNA-binding domain
Description:  The LytTR domain is a DNA-binding, potential winged helix-turn-helix (wHTH) domain of about 100 amino acids, present in bacterial transcriptional regulators of the algR/agrA/lytR family. It is named after Bacillus subtilis LytT and Staphylococcus aureus lytR response regulators, involved in the regulation of cell autolysis []. The LytTR domain is found in several bacterial cytoplasmic proteins that regulate the production of important virulence factors, like extracellular polysaccharides, toxins and bacteriocins. These response regulators of the microbial two-component signal transduction systems contain N-terminal cheY-like domains and the LytTR domain in the C-terminal part is expected to bind to specific DNA sequences in the upstream regions of target genes []. Other domains found N-terminally of LytTR are an ATP-binding domain of ABC-type transporter family and a PAS domain. Besides these cytoplasmic proteins, LytTR also occurs in membrane-bound bacterial proteins. The N-terminal parts of these proteins contain three to eight predicted transmembrane segments or the transmembrane MHYT domain.According to secondary structure predictions the LytTR domain consists of four beta-strands and three alpha-helices. The structure is predicted to form anovel type of DNA-binding domain, showing similarity to the 'winged HTH' or 'winged helix' proteins [, ]. Short Name:  LytTR_DNA-bd_dom
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF04397
PS50930
SM00850

6 Found Ins

DB identifier Type Name
IPR012073 Family LytTR MHYT transcriptional regulator
IPR012072 Family LytTR signal transduction protein, putative
IPR012046 Family LytTR transcriptional regulator with ABC transporter ATP-binding domain
IPR012362 Family LytTR transmembrane transcriptional regulator, putative
IPR012379 Family LytTR MHYE transcriptional regulator, putative
IPR012405 Family LytTR stand-alone protein

1 GO Annotation

GO Term Gene Name
GO:0003677 IPR007492

1 Ontology Annotations

GO Term Gene Name
GO:0003677 IPR007492

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30450.m000034 B9TEL6 PAC:16824429 Ricinus communis 180  
33382.m000018 B9TJK5 PAC:16825807 Ricinus communis 286  
36128.m000028 B9TEP0 PAC:16826885 Ricinus communis 246  
47075.m000013 B9TP28 PAC:16827956 Ricinus communis 252  
49961.m000026 B9TLS0 PAC:16828216 Ricinus communis 238  
28768.m000059 B9T9U7 PAC:16801681 Ricinus communis 182  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12034833
            12367524