Protein Domain : IPR026848

Type:  Family Name:  E3 ubiquitin-protein ligase FANCL
Description:  E3 ubiquitin-protein ligase FANCL belongs to the multisubunit FA complex. It is an ubiquitin ligase protein that mediates monoubiquitination of FANCD2, a key step in the repair of interstrand DNA crosslinks (ICLs) in the Fanconi anemia (FA) pathway [, ]. In humans, defects in FANCL are the cause of Fanconi anemia complementation group L (FANCL). FANCL is a disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair [, ]. Short Name:  Fancl
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR13206:SF0

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0004842 IPR026848
GO:0006281 IPR026848
GO:0043240 IPR026848

3 Ontology Annotations

GO Term Gene Name
GO:0004842 IPR026848
GO:0006281 IPR026848
GO:0043240 IPR026848

0 Parent Features

403 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
28830.m000220 B9T174 PAC:16801751 Ricinus communis 309  
orange1.1g022965m A0A067GJG1 PAC:18125017 Citrus sinensis 289  
AT5G65740.4 F4JXJ5 PAC:19672195 Arabidopsis thaliana 250  
AT5G65740.1 Q1ECQ9 PAC:19672196 Arabidopsis thaliana 216  
AT5G65740.2 B9DHA4 PAC:19672194 Arabidopsis thaliana 300  
AT5G65740.3 Q1ECQ9 PAC:19672197 Arabidopsis thaliana 216  
Thhalv10004606m V4KMV7 PAC:20200017 Eutrema salsugineum 321  
Ciclev10026132m V4SQL0 PAC:20800373 Citrus clementina 310  
Potri.007G008300.1 PAC:27016032 Populus trichocarpa 298  
Potri.007G008300.2 A0A3N7F6T1 PAC:27016034 Populus trichocarpa 294  
Potri.007G008300.3 PAC:27016033 Populus trichocarpa 297  
Gorai.003G033500.4 A0A0D2NVR4 PAC:26797068 Gossypium raimondii 268  
Gorai.003G033500.5 A0A0D2MIT5 PAC:26797069 Gossypium raimondii 263  
Gorai.003G033500.1 A0A0D2RFZ3 PAC:26797066 Gossypium raimondii 292  
Gorai.003G033500.3 A0A0D2QF34 PAC:26797067 Gossypium raimondii 289  
64092 I0Z934 PAC:27389395 Coccomyxa subellipsoidea C-169 388  
Thecc1EG000869t1 A0A061DH73 PAC:27433407 Theobroma cacao 292  
Thecc1EG000869t2 A0A061DHB9 PAC:27433408 Theobroma cacao 242  
Migut.H00314.1.p PAC:28950849 Mimulus guttatus 296  
Araha.1790s0004.1.p PAC:28853664 Arabidopsis halleri 287  
Cagra.0917s0011.1.p PAC:28909310 Capsella grandiflora 308  
Brara.F02445.1.p A0A397Z165 PAC:30629376 Brassica rapa FPsc 300  
Bostr.0568s0211.2.p PAC:30669624 Boechera stricta 287  
Bostr.0568s0211.1.p PAC:30669623 Boechera stricta 310  
Bostr.25993s0324.1.p PAC:30667784 Boechera stricta 99  
Cre03.g204801.t1.1 A0A2K3DZR3 PAC:30787779 Chlamydomonas reinhardtii 535  
Bradi1g10058.3.p PAC:31129196 Brachypodium distachyon 228  
Bradi1g10058.2.p PAC:31129195 Brachypodium distachyon 243  
SapurV1A.0821s0140.1.p PAC:31447271 Salix purpurea 239  
Spipo2G0112300 PAC:31510610 Spirodela polyrhiza 422  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            17938197
            12973351
            15502827
            22287633