Protein Domain : IPR023558

Type:  Domain Name:  Tryptophan RNA-binding attenuator protein domain
Description:  The tryptophan RNA-binding attenuation protein (TRAP) regulates expression of the tryptophan biosynthetic genes in Bacillus sp. by binding to the leader region of the nascent trp operon mRNA []. The crystal structure of the Trp RNA-binding attenuation protein of Bacillus subtilis(mtrB, ) has been solved []. TRAP forms an oligomeric ring consisting of 11 single-domain subunits, where each subunit adopts a double-stranded beta-helix structure with the appearance of a beta-sandwich of distinct architecture and jelly-roll fold. The 11 subunits are stabilised by 11 inter-subunit strands, forming a beta-wheel with a large central hole. TRAP is activated by binding to tryptophan in clefts between adjacent beta-strands, which induces conformational changes in the protein. Activated TRAP binds an mRNA target sequence consisting of 11 (G/U)AG repeats, separated by 2-3 spacer nucleotides. The spacer nucleotides do not make direct contact with the TRAP protein, but they do influence the conformation of the RNA, which might influence the specificity of TRAP [].This entry represents the structural domain in the TRAP family of proteins. Short Name:  Trp_RNA-bd_attenuator_dom

0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF02081
G3DSA:2.60.40.50

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR016031 Domain Tryptophan RNA-binding attenuator protein-like domain

14 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
29019.m000014 B9TCC9 PAC:16802177 Ricinus communis 108  
Traes_2AS_70A738C1B.21 PAC:31798169 Triticum aestivum 75  
Traes_2AS_70A738C1B.16 PAC:31798162 Triticum aestivum 93  
Traes_6DL_2EC7FE762.6 PAC:31926470 Triticum aestivum 62  
Traes_6DL_2EC7FE762.7 PAC:31926469 Triticum aestivum 62  
Brdisv1Bd21-3_r1026266m.p PAC:35562941 Brachypodium distachyon Bd21-3 821  
Kaladp0048s0511.1.p PAC:35742003 Kalanchoe fedtschenkoi 55  
Pavir.8NG126400.1.p PAC:37624019 Panicum virgatum 103  
HORVU6Hr1G075400.15 PAC:38506980 Hordeum vulgare 148  
HORVU6Hr1G075400.14 PAC:38506979 Hordeum vulgare 184  
HORVU6Hr1G075400.13 PAC:38506978 Hordeum vulgare 193  
Mamar.0004s0148.1.p PAC:39430167 Malcolmia maritima 170  
Eusyr.0014s0055.1.p PAC:39686929 Euclidium syriacum 460  
Pavir.8NG126400.1.p PAC:41634592 Panicum virgatum 103  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7715723
            15050822
            11914485