| Type: | Domain | Name: | Plasmid maintenance toxin/Cell growth inhibitor |
| Description: | Bacterial cells remove plasmid-free segregants by the use of toxin/antitoxin systems, where cells that lack plasmids cannot produce the antitoxin required for survival. Several of the toxin components have similar structures, which consists of an SH3-like barrel fold, and contains an inserted beta-sheet subdomain and a C-terminal helix, despite often low sequence identities. Toxins that have this structural fold include CcdB from Escherichia coli, a topoisomerase poison that interferes with DNA gyrase activity [], PemK-like YdcE from Bacillus subtilis, Kid toxin (Kis antitoxin) from the E. coli R1 plasmid [], and the MazF toxin (MazE antitoxin) from E. coli []. | Short Name: | Plasmid_toxin/cell-grow_inhib |
