Protein Domain : IPR001875

Type:  Domain Name:  Death effector domain
Description:  The death effector domain (DED) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DED is related in sequence and structure to the death domain (DD, see ) and the caspase recruitment domain (CARD, see ), which work in similar pathways and show similar interaction properties []. The dimerisation of DED domains is mediated primarily by electrostatic interactions. DED domains can be found in isolation, or in combination with other domains. Domains associated with DED include: caspase catalytic domains (in caspase-8, -10), death domains (in FADD), nuclear localisation sequences (in DEDD), transmembrane domains (in Bap31 and Bar), nucleotide-binding domains (in Dap3), coiled-coil domains (in Hip and Hippi), SAM domains (in Bar), and E2-binding RING domains (in Bar) [].Several DED-containing proteins are involved in the regulation of apoptosis through their interactions with DED-containing caspases (), such as caspases 8 and 10 in humans, both of which contain tandem pairs of DEDs. There are many DED-containing modulators of apoptosis, which can either enhance or inhibit caspase activation []. Short Name:  DED_dom
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF01335
PS50168
SM00031

1 Found In

DB identifier Type Name
IPR016729 Family FADD

2 GO Annotations

GO Term Gene Name
GO:0005515 IPR001875
GO:0042981 IPR001875

2 Ontology Annotations

GO Term Gene Name
GO:0005515 IPR001875
GO:0042981 IPR001875

1 Parent Features

DB identifier Type Name
IPR011029 Domain Death-like domain

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
GlymaLee.12G118100.8.p PAC:41298754 Glycine max Lee 918  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11504623
            15226512
            15173180