Protein Domain : IPR004020

Type:  Domain Name:  DAPIN domain
Description:  The DAPIN (Domain in Apoptosis and INterferon response) domain is an 80-100- residue domain which is found in the N terminus of diverse vertebrate andvertebrate-specific viral proteins involved in apoptosis, cancer, inflammation, and immune response. The DAPIN domain can be found alone or inassociation with other domains [, , ] like CARD, LRR, SPRY, Caspase or Zinc finger B-box. It has been proposed that the DAPIN domain might have an adaptor function, coupling apoptosis and immune disorders [, , ]. It has been shown that the DAPIN domain is a protein-protein interaction domain capable of binding to other DAPIN domains [].Secondary structure predictions have identified the DAPIN domain as mostly alpha-helical and it has been suggested that it could belong to the DEATH-domain-fold superfamily, which includes the CARD, the DEATH domain (DD) and the DEATH effector domain (DED) [, , ].The DAPIN domain has also been called pyrin domain, pyrin N-terminal homology domain (PYD) or PAAD (after the protein families pyrin, AIM, ASC death-domain-like) [, ]. Short Name:  DAPIN

0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF02758
PS50824

0 Found In

0 GO Annotation

0 Ontology Annotations

1 Parent Features

DB identifier Type Name
IPR011029 Domain Death-like domain

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30128.m008540 B9RFY4 PAC:16818130 Ricinus communis 241  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11166557
            11166558
            11250163
            1166557