| Type: | Family | Name: | Pantothenate kinase, acetyl-CoA regulated, two-domain type |
| Description: | Pantothenate kinase (PanK, ) catalyses the conversion of CAATP and pantothenate to ADP and D-4'-phosphopantothenate, the key regulatory step in the biosynthesis of coenzyme A (CoA) []. Members in this entry represents a two-domain form with an additional C-terminal domain of unknown function. represents the single-domain form of PanK.This type of pantothenate kinase is typical for eukaryotes. It is not related by sequence to bacterial PanK () and differs in a number of biochemical properties (such as inhibition by acetyl-CoA) [, ]. However, this group also includes proteins from several Gram-positive bacteria () that are suggested to have originated from the eukaryotic form by lateral transfer [].Hallervorden-Spatz syndrome is caused by a defect in a pantothenate kinase gene [].For additional information please see []. | Short Name: | PanK_long |
