Type: | Domain | Name: | Colicin/pyocin immunity protein domain |
Description: | Bacterial colicin and pyocin immunity proteins [, ] can bind specifically to the DNase-type colicins and pyocins and inhibit their bactericidal activity. The1.8-angstrom crystal structure of the ImmE7 protein consists of four antiparallel alpha-helices []. Sequence similarities between colicins E2, A and E1 [] are less striking. The colicinE2 (pyocin) immunity protein does not share similarity with either the colicin E3 or cloacin DF13 [] immunity proteins. Pyocin protects a cell that harbours the plasmidColE2 encoding colicin E2 against colicin E2; it is thus essential both for autonomous replication and colicin E2 immunity [].This entry represents the structural domain of colicin and pyocin immunity proteins. | Short Name: | Colicin/pyocin_immunity_dom |