| Type: | Family | Name: | Histone deacetylase complex, subunit 2/3 |
| Description: | This entry contains the class II histone deacetylase complex subunits HDA2 and HDA3 from fungi. The member from Schizosaccharomyces pombe(Fission yeast) is referred to as Ccq1 in . These proteins associate with HDA1 to generate the activity of the HDA1 histone deacetylase complex. HDA1 interacts with itself and with the HDA2-HDA3 subcomplex to form a probable tetramer and these interactions are necessary for catalytic activity. The HDA1 histone deacetylase complex is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. HDA2 and HDA3 have a conserved coiled-coil domain towards their C terminus []. | Short Name: | HDA_complex_subunit-2/3 |
