Protein Domain : IPR002747

Type:  Family Name:  SAM-dependent chlorinase/fluorinase
Description:  Adenosyl-chloride synthase or chlorinase SalL mediates catalyses the halogenation of S-adenosyl-L-methionine (SAM) with chloride to generate 5'-chloro-5'-deoxyadenosine (5'-CIDA) and L-methionine []. The fluorinase FlA from Streptomyces cattleya is involved in the synthesis of fluorometabolites and has homology to SalL []. It catalyses the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine [], but it can also function as a chlorinase []. This family also includes chlorinase MJ1651 from Methanocaldococcus jannaschii. Its protein structure is most closely related to the bacterial fluorinating enzyme; however, it may have different function []. Short Name:  SAM_Chlor/Fluor
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1 Child Features

DB identifier Type Name
IPR030978 Family Adenosyl-fluoride synthase

0 Contains

2 Cross Referencess

Identifier
PF01887
PIRSF006779

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30938.m000027 PAC:16824718 Ricinus communis 218  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16370017
            17910070
            18059261
            17985882
            18675376