Protein Domain : IPR023228

Type:  Domain Name:  S-adenosyl-l-methionine hydroxide adenosyltransferase, N-terminal
Description:  The S-adenosyl-L-methionine (SAM) hydroxide adenosyltransferase family groups several fluorinase and chlorinase enzymes whose common feature is that they mediate nucleophilic reactions of their respective halide ions to the C-5' carbon of SAM []. These enzymes utilise a rigorously conserved amino acid side chain triad (Asp-Arg-His) which may have a role in activating water to hydroxide ion. Structural studies indicate that the protein is a homotrimer, with each monomer being composed of N- and C-terminal domains [, ]. The N-terminal domain has a central seven-stranded beta-sheet, which combines parallel and antiparallel strands sandwiched between alpha helices. The C-terminal domain forms a beta-barrel with a greek-key topology. SAM is bound at the interface between the C-terminal domain of one monomer and the N-terminal domain of the neighbouring monomer, with a total of three molecules bound by the trimer.This entry represents the N-terminal domain of these proteins. Short Name:  SAM_OH_AdoTrfase_N
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0 Child Features

0 Contains

1 Cross References

Identifier
SSF102522

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

11 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
30938.m000027 PAC:16824718 Ricinus communis 218  
Lus10027244 PAC:23145543 Linum usitatissimum 396  
Pahal.I00479.1 PAC:32502563 Panicum hallii 557  
Brdisv1Jer11045944m.p PAC:35464000 Brachypodium distachyon Jer1 109  
Pavir.3KG333500.1.p PAC:37593648 Panicum virgatum 844  
Alyli.0075s0070.1.p PAC:39174705 Alyssum linifolium 526  
Desop.0030s0207.1.p PAC:39661751 Descurainia sophioides 526  
Distr.0243s0079.1.p PAC:40014243 Diptychocarpus strictus 526  
Pavir.3KG333500.1.p PAC:41615226 Panicum virgatum 855  
Distr.0003s66664.1.p PAC:45555315 Diptychocarpus strictus 526  
Pahal.9G598350.1.p PAC:45931473 Panicum hallii 308  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18059261
            18675376
            14765200