Protein Domain : IPR004149

Type:  Domain Name:  Zinc-finger, NAD-dependent DNA ligase C4-type
Description:  Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis(African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [, , , , ]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few []. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. This entry represents the zinc finger domain found in NAD-dependent DNA ligases. DNA ligases catalyse the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor []. This domain is a small zinc binding motif that is presumably DNA binding. It is found only in NAD-dependent DNA ligases. Short Name:  Znf_DNAligase_C4
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0 Child Features

0 Contains

1 Cross References

Identifier
PF03119

3 Found Ins

DB identifier Type Name
IPR010994 Domain RuvA domain 2-like
IPR001679 Family NAD-dependent DNA ligase
IPR013840 Domain NAD-dependent DNA ligase, N-terminal

3 GO Annotations

GO Term Gene Name
GO:0003911 IPR004149
GO:0006260 IPR004149
GO:0006281 IPR004149

3 Ontology Annotations

GO Term Gene Name
GO:0003911 IPR004149
GO:0006260 IPR004149
GO:0006281 IPR004149

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
31200.m000015 B9TDA3 PAC:16824879 Ricinus communis 491  
29450 A4SB11 PAC:27420309 Ostreococcus lucimarinus 755  
Pp3s32_280V3.1.p PAC:32948403 Physcomitrium patens 2359  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12665246
            15718139
            17210253
            15963892
            10529348
            11179890
            10698952