Protein Domain : IPR005074

Type:  Domain Name:  Peptidase C39, bacteriocin processing
Description:  This group of sequences defined by this cysteine peptidase domain belong to the MEROPS peptidase family C39 (clan CA). It is found in a wide range of ABC transporters, which are maturation proteases for peptide bacteriocins, the proteolytic domain residing in the N-terminal region of the protein []. A number of the proteins are classified as non-peptidase homologues as they either have been found experimentally to be without peptidase activity, or lack amino acid residues that are believed to be essential for the catalytic activity.Lantibiotic and non-lantibiotic bacteriocins are synthesised as precursor peptides containing N-terminal extensions (leader peptides) which are cleaved off during maturation. Most non-lantibiotics and also some lantibiotics have leader peptides of the so-called double-glycine type. These leader peptides share consensus sequences and also a common processing site with two conserved glycine residues in positions -1 and -2. The double- glycine-type leader peptides are unrelated to the N-terminal signal sequences which direct proteins across the cytoplasmic membrane via the sec pathway. Their processing sites are also different from typical signal peptidase cleavage sites, suggesting that a different processing enzyme is involved. Short Name:  Peptidase_C39
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0 Child Features

0 Contains

2 Cross Referencess

Identifier
PF03412
PS50990

4 Found Ins

DB identifier Type Name
IPR017750 Family ATPase, type I secretion system
IPR010132 Domain ATPase, type I secretion system, HlyB
IPR022514 Family NHPM bacteriocin system ABC transporter, peptidase/ATP-binding protein
IPR005897 Family Peptidase C39, ABC-type bacteriocin transporter

4 GO Annotations

GO Term Gene Name
GO:0005524 IPR005074
GO:0008233 IPR005074
GO:0006508 IPR005074
GO:0016021 IPR005074

4 Ontology Annotations

GO Term Gene Name
GO:0005524 IPR005074
GO:0008233 IPR005074
GO:0006508 IPR005074
GO:0016021 IPR005074

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
31711.m000030 B9TFS4 PAC:16825159 Ricinus communis 253  
33365.m000018 B9TIV8 PAC:16825794 Ricinus communis 301  
Medtr1309s0010.1 A0A072TP64 PAC:31092104 Medicago truncatula 652  
AH023014-RA PAC:38164960 Amaranthus hypochondriacus 230  

1 Publications

First Author Title Year Journal Volume Pages PubMed ID
            7674922