Protein Domain : IPR005252

Type:  Family Name:  Coenzyme A biosynthesis bifunctional protein CoaBC
Description:  This entry represents a bifunctional enzyme CoaBC (gene name dfp) that catalyses the second and third steps (cysteine ligation, (), and decarboxylation, ()) in the biosynthesis of coenzyme A (CoA) from pantothenate in bacteria. This enzyme contains the FMN cofactor, but no FAD or pyruvoyl group. The amino-terminal region is responsible for the phosphopantothenoylcysteine decarboxylase activity [].The protein product of the dfp gene in Escherichia coli was found to be able to restore a temperature-sensitive conditionally lethal mutation that resulted in a slow cessation of DNA synthesis []. The protein encoded by dfp was then found to affect both DNA and pantothenate metabolism []. Later, phosphopantothenate-cysteine ligase activity, which is involved in the biosynthesis of coenzyme A, was demonstrated in the same protein. Therefore this protein has been named bifunctional protein CoaBC []. Short Name:  CoaBC
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0 Child Features

2 Contains

DB identifier Type Name
IPR007085 Domain DNA/pantothenate metabolism flavoprotein, C-terminal
IPR003382 Domain Flavoprotein

1 Cross References

Identifier
TIGR00521

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0004632 IPR005252
GO:0004633 IPR005252
GO:0010181 IPR005252
GO:0015937 IPR005252
GO:0015941 IPR005252

5 Ontology Annotations

GO Term Gene Name
GO:0004632 IPR005252
GO:0004633 IPR005252
GO:0010181 IPR005252
GO:0015937 IPR005252
GO:0015941 IPR005252

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
32058.m000015 B9TIY6 PAC:16825287 Ricinus communis 370  
Pp3s46_18V3.1.p PAC:32948217 Physcomitrium patens 412  
Brdisv1BdTR11A1045309m.p PAC:35696266 Brachypodium distachyon BdTR11a 208  
Brdisv1BdTR11A1045343m.p PAC:35694613 Brachypodium distachyon BdTR11a 402  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11278255
            3123465
            2999089