1 Found In
| DB identifier | Type | Name |
|---|---|---|
| IPR014506 | Family | Uncharacterised conserved protein UCP020479, signal transduction CheW-like |
3 Ontology Annotations
| GO Term | Gene Name |
|---|---|
| GO:0004871 | IPR002545 |
| GO:0006935 | IPR002545 |
| GO:0007165 | IPR002545 |
| Type: | Domain | Name: | CheW-like domain |
| Description: | The CheW-like domain is an around 150-residue domain that is found in proteins involved in the two-component signaling systems regulating bacterial chemotaxis. Two components systems are composed of a receptor kinase, whichmonitors the environmental conditions and its substrate, the response regulator, which acts as a binary switch depending on the phosphorylationstate. In Escherichia coli, the signal transduction pathway for chemotaxis consists of specialised membrane receptors, termed chemotaxis transducers; aCheA-CheY two-component system, which transmits the signal from transducers to flagellar motors; and a docking protein, CheW, which couples the CheAhistidine kinase to transducers. Whereas CheW is only made of a CheW-like domain, CheA additionally contains an HPt domain and anhistidine kinase domain. The CheW-like domain has been shown to mediate the interaction between CheA and the adaptor protein CheW. Somebacteria contain another bifunctional protein, CheV, consisting of an N- terminal CheW-like domain and a C-terminal response regulatory domain. Although its precise function in chemotaxis is unknown, CheVprobably acts in adaptation to attractants [, , , ].The CheW-like domain is composed of two beta-sheet subdomains, each of which forms a loose five-stranded beta-barrel around an internal hydrophobic core. The interactions between the subdomains are contributed by athird hydrophobic core sandwiched between the two beta-sheet subdomains. The CheW-like structure is stabilised by extensive hydrophobic interactions [, ]. | Short Name: | CheW |
| DB identifier | Type | Name |
|---|---|---|
| IPR014506 | Family | Uncharacterised conserved protein UCP020479, signal transduction CheW-like |
| GO Term | Gene Name |
|---|---|
| GO:0004871 | IPR002545 |
| GO:0006935 | IPR002545 |
| GO:0007165 | IPR002545 |
