Protein Domain : IPR013118

Type:  Domain Name:  Mannitol dehydrogenase, C-terminal
Description:  Long-chain mannitol dehydrogenases are a group of secondary alcohol dehydrogenases that differ from other alcohol or polyol dehydrogenases in that they do not utilise Zn(2+) or other metal cofactors and do not contain a conserved catalytic tyrosine residue. The proteins in this family that have been studied are monomeric enzymes of ~54 kDa and include: Mannitol-1-phosphate 5-dehydrogenase () []Mannitol 2-dehydrogenase () []D-arabinitol 4-dehydrogenase () []Altronate oxidoreductase ()D-mannonate oxidoreductase ()These enzymes are mostly found in bacteria, though they are also present in some fungal species. This entry represents the C-terminal substrate-binding domain of long-chain mannitol dehydrogenases. This domain is primarily alpha-helical in nature, being composed of eleven helices and a small beta hairpin []. Most of the residues implicated in substrate binding are located within this region, and a conserved lysine residue is thought to act as a proton acceptor during catalysis. Short Name:  Mannitol_DH_C
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0 Child Features

0 Contains

1 Cross References

Identifier
PF08125

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0016491 IPR013118
GO:0050662 IPR013118
GO:0055114 IPR013118

3 Ontology Annotations

GO Term Gene Name
GO:0016491 IPR013118
GO:0050662 IPR013118
GO:0055114 IPR013118

1 Parent Features

DB identifier Type Name
IPR013328 Domain 6-phosphogluconate dehydrogenase, domain 2

29 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
213628 C1N0F0 PAC:27340551 Micromonas pusilla CCMP1545 560  
125487 PAC:27340467 Micromonas pusilla CCMP1545 647  
62890 C1FJR7 PAC:27399803 Micromonas sp RCC299 570  
62889 C1FJR8 PAC:27399968 Micromonas sp RCC299 634  
Araha.11756s0241.1.p PAC:28856458 Arabidopsis halleri 386  
Brdisv1pangenome1006393m.p PAC:33619083 Brachypodium distachyon Pangenome 298  
Brdisv1pangenome1007266m.p PAC:33641287 Brachypodium distachyon Pangenome 970  
Brdisv1pangenome1007313m.p PAC:33624535 Brachypodium distachyon Pangenome 291  
Brdisv1pangenome1006906m.p PAC:33655329 Brachypodium distachyon Pangenome 507  
Brdisv1pangenome1008114m.p PAC:33620598 Brachypodium distachyon Pangenome 537  
Brdisv1pangenome1009028m.p PAC:33624396 Brachypodium distachyon Pangenome 496  
Brdisv1pangenome1009902m.p PAC:33607277 Brachypodium distachyon Pangenome 382  
Brdisv1BdTR8i1044470m.p PAC:34242240 Brachypodium distachyon BdTR8i 298  
Brdisv1BdTR12c1040000m.p PAC:34405525 Brachypodium distachyon BdTR12c 458  
Brdisv1BdTR11G1006512m.p PAC:34614623 Brachypodium distachyon BdTR11g 388  
Brdisv1BdTR11A1045451m.p PAC:35695124 Brachypodium distachyon BdTR11a 493  
Brdisv1BdTR11A1043397m.p PAC:35696690 Brachypodium distachyon BdTR11a 573  
Brdisv1BdTR11A1042172m.p PAC:35690172 Brachypodium distachyon BdTR11a 558  
Brdisv1BdTR11A1040096m.p PAC:35695183 Brachypodium distachyon BdTR11a 507  
Brdisv1BdTR11A1040738m.p PAC:35690380 Brachypodium distachyon BdTR11a 382  
Brdisv1BdTR11A1042114m.p PAC:35688106 Brachypodium distachyon BdTR11a 970  
Brdisv1BdTR11A1037380m.p PAC:35684561 Brachypodium distachyon BdTR11a 523  
Thint.V1707100.1.p PAC:40758134 Thinopyrum intermedium 445  
Cocit.L5128.1.p PAC:41052938 Corymbia citriodora 316  
Nycol.A03562.1.p PAC:44495327 Nymphaea colorata 370  
33267.m000028 B9TE50 PAC:16825755 Ricinus communis 319  
33267.m000028 B9TE50 PAC:16825755 Ricinus communis 319  
36037.m000014 B9TL38 PAC:16826851 Ricinus communis 315  
36037.m000014 B9TL38 PAC:16826851 Ricinus communis 315  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8254318
            9639934
            12196534
            11160802