Protein Domain : IPR001712

Type:  Family Name:  Type III secretion system FHIPEP
Description:  The Flagellar/Hr/Invasion Proteins Export Pore (FHIPEP) family [, ] consists of a number of proteins that constitute the type III secretion (or signal peptide-independent) pathway apparatus [, ]. This mechanism translocates proteins lacking an N-terminal signal peptide across the cell membrane in one step, as it does not require an intermediate periplasmic process to cleave the signal peptide. It is a common pathway amongst Gram-negative bacteria for secreting toxic and flagellar proteins.The pathway apparatus comprises three components: two within the inner membrane and one within the outer []. An FHIPEP protein is located within the inner membrane, although it is unknown which component it constitutes. FHIPEP proteins have all about 700 amino-acid residues. Within the sequence, the N terminus is highly conserved and hydrophobic, suggesting that this terminus is embedded within the membrane, with 6-8 transmembrane (TM) domains, while the C terminus is less conserved and appears to be devoid of TM regions. It is possible that members of the FHIPEP family serve as pores for the export of specific proteins. Short Name:  T3SS_FHIPEP
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2 Child Features

DB identifier Type Name
IPR006301 Family Flagellar biosynthesis protein FlhA
IPR006302 Family Type III secretion protein HrcV

0 Contains

3 Cross Referencess

Identifier
PF00771
PIRSF005419
PR00949

0 Found In

2 GO Annotations

GO Term Gene Name
GO:0009306 IPR001712
GO:0016020 IPR001712

2 Ontology Annotations

GO Term Gene Name
GO:0009306 IPR001712
GO:0016020 IPR001712

0 Parent Features

3 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
33870.m000018 B9TLJ7 PAC:16826021 Ricinus communis 307  
Araha.11756s0444.1.p PAC:28856444 Arabidopsis halleri 683  
Brdisv1BdTR11A1049766m.p PAC:35687851 Brachypodium distachyon BdTR11a 273  

4 Publications

First Author Title Year Journal Volume Pages PubMed ID
            1592799
            1365398
            8253684
            8316211