Protein Domain : IPR003646

Type:  Domain Name:  SH3-like domain, bacterial-type
Description:  SH3 (src Homology-3) domains are small protein modules containing approximately 50 amino acid residues [, ]. They are found in a great variety of intracellular or membrane-associated proteins [, , ] for example, in a variety of proteins with enzymatic activity, in adaptor proteins, such as fodrin and yeast actin binding protein ABP-1.The SH3 domain has a characteristic fold which consists of five or six beta-strands arranged as two tightly packed anti-parallel beta sheets. The linker regions may contain short helices. The surface of the SH3-domain bears a flat, hydrophobic ligand-binding pocket which consists of three shallow grooves defined by conservative aromatic residues in which the ligand adopts an extended left-handed helical arrangement. The ligand binds with low affinity but this may be enhanced by multiple interactions. The region bound by the SH3 domain is in all cases proline-rich and contains PXXP as a core-conserved binding motif. The function of the SH3 domain is not well understood but they may mediate many diverse processes such as increasing local concentration of proteins, altering their subcellular location and mediating the assembly of large multiprotein complexes [].A homologue of the SH3 domain has been found in a number of different bacterial proteins including glycyl-glycine endopeptidase, bacteriocin and some hypothetical proteins. Short Name:  SH3-like_bac-type
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0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF08239
PF08460
SM00287

1 Found In

DB identifier Type Name
IPR010466 Family Protein of unknown function DUF1058

0 GO Annotation

0 Ontology Annotations

0 Parent Features

9 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
34572.m000027 B9TEF3 PAC:16826265 Ricinus communis 371  
Sphfalx0035s0163.1.p PAC:32618606 Sphagnum fallax 111  
Sphfalx0000s0525.1.p PAC:32614631 Sphagnum fallax 111  
Sphfalx0692s0001.1.p PAC:32619287 Sphagnum fallax 111  
Pp3s196_10V3.1.p PAC:32926447 Physcomitrium patens 851  
Brdisv1BdTR12c1005885m.p PAC:34398888 Brachypodium distachyon BdTR12c 1070  
Sphfalx08G105800.1.p PAC:41994286 Sphagnum fallax 111  
Sphfalx08G106200.1.p PAC:41993249 Sphagnum fallax 111  
Sphfalx08G106100.1.p PAC:41992817 Sphagnum fallax 111  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15335710
            7531822
            14731533
            7953536
            1639195
            11256992