Protein Domain : IPR005143

Type:  Domain Name:  Transcription factor LuxR-like, autoinducer-binding domain
Description:  This domain binds N-acyl homoserine lactones (AHLs), which are also known as autoinducers. These are small, diffusible molecules used as communication signals in a large variety of proteobacteria. It is almost always found in association with the DNA-binding LuxR domain (). The autoinducer binding domain forms the N-terminal region of the protein, while the DNA-binding domain forms the C-terminal region. In most cases, binding of AHL by this N-terminal domain leads to unmasking of the DNA-binding domain, allowing it to bind DNA and activate transcription []. In rare cases, some LuxR proteins such as EsaR, act as repressors []. In these proteins binding of AHL to this domain leads to inactivation of the protein as a transcriptional regulator. A large number of processes have been shown to be regulated by LuxR proteins, including bioluminescence, production of virulence factors in plant and animal pathogens, antibiotic production and plasmid transfer.Structural studies of TraR from Agrobacterium tumefaciens[, ] show that the functional protein is a homodimer. Binding of the cognate AHL is required for protein folding, resistance to proteases and dimerisation. The autoinducer binding domain binds its cognate AHL in an alpha/beta/alpha sandwich and provides an extensive dimerisation surface, though residues from the C-terminal region also make some contribution to dimerisation. The autoinducer binding domain is also required for interaction with RpoA, allowing transcription to occur [].There are some proteins which consist solely of the autoinducer binding domain. The function of these is not known, but TrlR from Agrobacterium has been shown to inhibit the activity of TraR by the formation of inactive heterodimers []. Short Name:  TF_LuxR_autoind-bd_dom

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF03472
G3DSA:3.30.450.80
SSF75516

1 Found In

DB identifier Type Name
IPR019941 Family Transcription regulator LuxR, chaperone HchA-associated

0 GO Annotation

0 Ontology Annotations

0 Parent Features

58 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
57773.m000018 B9TKR4 PAC:16829074 Ricinus communis 234  
60679 C1FFZ2 PAC:27403384 Micromonas sp RCC299 98  
Araha.22879s0001.1.p PAC:28853008 Arabidopsis halleri 209  
Brara.J02550.1.p A0A397XNF2 PAC:30612087 Brassica rapa FPsc 159  
Medtr4g129620.1 A0A072URZ2 PAC:31106570 Medicago truncatula 180  
Medtr4g129620.2 A0A072V355 PAC:31106569 Medicago truncatula 194  
Medtr4g129620.4 A0A072UTA8 PAC:31106572 Medicago truncatula 170  
Medtr4g129620.3 A0A072UTA8 PAC:31106573 Medicago truncatula 170  
Medtr4g129620.5 A0A072URZ2 PAC:31106571 Medicago truncatula 180  
Traes_3AL_72DA6C7BE.1 PAC:31745006 Triticum aestivum 238  
Traes_3B_1B3493811.8 PAC:32002352 Triticum aestivum 428  
Traes_3DL_D1CF4784D.4 PAC:31786662 Triticum aestivum 303  
Traes_3DL_D1CF4784D.5 PAC:31786663 Triticum aestivum 303  
Tp57577_TGAC_v2_mRNA5529 PAC:35972821 Trifolium pratense 180  
DCAR_016222 PAC:36076596 Daucus carota 1014  
Pum1940s0001.1.p A0A1X6NKA1 PAC:38014182 Porphyra umbilicalis 97  
HORVU4Hr1G011500.2 PAC:38573300 Hordeum vulgare 63  
Myper.0023s0484.1.p PAC:39123057 Myagrum perfoliatum 159  
Roisl.0008s0174.1.p PAC:39211406 Rorippa islandica 402  
Isati.19019s0001.1.p PAC:39353369 Isatis tinctoria 385  
Isati.4786s0003.1.p PAC:39311636 Isatis tinctoria 159  
Isati.4786s0007.1.p PAC:39311639 Isatis tinctoria 157  
Isati.4786s0005.1.p PAC:39311632 Isatis tinctoria 157  
Isati.0698s0037.1.p PAC:39329262 Isatis tinctoria 157  
Sialb.0050s0129.1.p PAC:39582724 Sinapis alba 159  
Clevi.0012s0879.2.p PAC:39728652 Cleome violacea 69  
Clevi.0012s0879.1.p PAC:39728651 Cleome violacea 69  
Eruve.0819s0018.1.p PAC:39873347 Eruca vesicaria 623  
Eruve.1006s0014.1.p PAC:39958823 Eruca vesicaria 484  
Eruve.6162s0001.1.p PAC:39954965 Eruca vesicaria 606  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            12087407
            11544353
            12067349
            12198141
            11309123
            15237104