Protein Domain : IPR011998

Type:  Domain Name:  Flavivirus glycoprotein central and dimerisation domain
Description:  Flaviviruses and alphaviruses are arthropod-borne, enveloped RNA viruses that cause infections in vertebrate hosts []. These viruses have two envelope glycoproteins (also known as 'spike' glycoproteins), one that undergoes proteolytic cleavage to prime the virus (glycoproteins M and P62 in flaviviruses and alphaviruses, respectively), and the other to mediate receptor binding and fusion (glycoproteins E and E1 in flaviviruses and alphaviruses, respectively). Glycoprotein E/E1 is comprised of three domains: domain I (dimerisation domain) is a beta-barrel, domain II (central domain) is an elongated beta-stranded and alpha-helical domain, and domain III (immunoglobulin-like domain) is an IgC-like beta-sandwich. This entry represents the intertwined central and dimerisation domains found in flaviviral glycoprotein E [] and alphaviral glycoprotein E1 [] proteins. Short Name:  Glycoprot_cen/dimer
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0 Child Features

3 Contains

DB identifier Type Name
IPR013754 Domain Glycoprotein E dimerisation domain
IPR013756 Domain Glycoprotein E central domain, subdomain 2
IPR013755 Domain Flaviviral glycoprotein, central domain, subdomain 1

2 Cross Referencess

Identifier
PF00869
SSF56983

1 Found In

DB identifier Type Name
IPR002548 Domain Alphavirus E1 glycoprotein

1 GO Annotation

GO Term Gene Name
GO:0046983 IPR011998

1 Ontology Annotations

GO Term Gene Name
GO:0046983 IPR011998

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Bostr.9600s0012.1.p PAC:30672121 Boechera stricta 51  
DCAR_023821 PAC:36058541 Daucus carota 678  
Podel.02G249700.1.p PAC:37297890 Populus deltoides WV94 69  
HORVU5Hr1G010120.3 PAC:38432244 Hordeum vulgare 143  
HORVU5Hr1G010120.2 PAC:38432243 Hordeum vulgare 143  
Luann.0002s0131.1.p PAC:39379943 Lunaria annua 134  
Eruve.6435s0005.1.p PAC:39932495 Eruca vesicaria 271  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15378043
            12759475
            11301009