Protein Domain : IPR002153

Type:  Family Name:  Transient receptor potential channel, canonical
Description:  TRP (transient receptor potential) channels can be described as tetramers formed by subunits with six transmembrane domains and containing cation-selective pores, which in several cases show high calcium permeability. The molecular architecture of TRP channels is reminiscent of voltage-gated channels and comprises six putative transmembrane segments (S1-S6), intracellular N- and C-termini, and a pore-forming reentrant loop between S5 and S6 [].TRP channels represent a superfamily conserved from worms to humans that comprise seven subfamilies []: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin or long TRPs), TRPA (ankyrin), whose only member is the transmembrane protein 1, TRPP(polycystin), TRPML (mucolipin) and TRPN (Nomp-C homologues), which has a single member that can be found in worms, flies, and zebrafish. TRPs are classified essentially according to their primary amino acid sequence rather than selectivity or ligand affinity, due to their heterogenous properties and complex regulation.TRP channels are involved in many physiological functions, ranging from pure sensory functions, such as pheromone signalling, taste transduction, nociception, and temperature sensation, over homeostatic functions, such as Ca2+ and Mg2+ reabsorption and osmoregulation, to many other motile functions, such as muscle contraction and vaso-motor control [].The classical or canonical TRPC family (formerly short-TRPs, STRPs) encompasses channels presenting a large number of different activation modes. Some are store-operated, whereas others are receptor-operated channels activated by the production of diacylglicerol or redox processes. TRPC proteins also control growth cone guidance in both mammalian and amphibian model systems. All seven channels of this family share the common property of activation through phospholipase C (PLC)-coupled receptors []. It is believed that functional TRPC channels are generated in situ by association of four TRPC proteins to form either homotetramers or heterotetramers []. Short Name:  TRPC_channel
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8 Child Features

DB identifier Type Name
IPR029877 Family Transient receptor potential-gamma protein
IPR005457 Family Transient receptor potential channel, canonical 1
IPR005460 Family Transient receptor potential channel, canonical 4
IPR005463 Family Transient receptor potential channel, canonical 7
IPR005458 Family Transient receptor potential channel, canonical 2
IPR005459 Family Transient receptor potential channel, canonical 3
IPR005461 Family Transient receptor potential channel, canonical 5
IPR005462 Family Transient receptor potential channel, canonical 6

0 Contains

2 Cross Referencess

Identifier
PTHR10117
PR01097

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0005262 IPR002153
GO:0070588 IPR002153
GO:0016020 IPR002153

3 Ontology Annotations

GO Term Gene Name
GO:0005262 IPR002153
GO:0070588 IPR002153
GO:0016020 IPR002153

1 Parent Features

DB identifier Type Name
IPR004729 Family Transient receptor potential channel

9 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cre10.g420500.t1.1 A0A2K3D953 PAC:30790694 Chlamydomonas reinhardtii 1343  
Cre10.g452950.t1.1 Q0Z852 PAC:30789968 Chlamydomonas reinhardtii 901  
Cre03.g153950.t1.1 A0A2K3DVV6 PAC:30787414 Chlamydomonas reinhardtii 1425  
Cre03.g175050.t1.1 A0A2K3DXC0 PAC:30787392 Chlamydomonas reinhardtii 1304  
Cre09.g397142.t1.1 A0A2K3DEN8 PAC:30780898 Chlamydomonas reinhardtii 2340  
Cre09.g390578.t1.1 A0A2K3DE40 PAC:30781341 Chlamydomonas reinhardtii 1404  
Dusal.0061s00028.2.p PAC:33190684 Dunaliella salina 581  
Dusal.0061s00028.1.p PAC:33190683 Dunaliella salina 770  
Vocar.0004s0402.1.p PAC:32889726 Volvox carteri 981  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            18535090
            20025796
            20861159
            15909153
            12032305