Protein Domain : IPR027625

Type:  Domain Name:  Putative 4-mercaptohistidine N1-methyltranferase, OvoA C-terminal domain
Description:  Ovothiol A is an N1-methyl-4-mercaptohistidine. Ovothiols are efficient scavengers of radicals and peroxides with possible roles in the redox defense of a number of organisms [, ]. An ovothiol biosynthetic enzyme (OvoA) has been identified in Erwinia tasmaniensis and Trypanosoma cruzi, with homologous enzymes encoded in more than 80 genomes ranging from proteobacteria to animalia [].OvoA has 5-histidylcysteine sulfoxide synthase activity. In the absence of S-adenosylmethione, a methyl donor, the intermediate produced is 4-mercaptohistidine. The enzymes of Erwinia tasmaniensis, Trypanosoma cruzi and most homologues share an additional C-terminal methyltransferase domain. Thus OvoA may be a bifunctional enzyme with 5-histidylcysteine sulfoxide synthase and 4-mercaptohistidine N1-methyltranferase activity. This entry describes the C-terminal putative 4-mercaptohistidine N1-methyltranferase domain. Short Name:  OvoA_Cterm
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0 Child Features

0 Contains

1 Cross References

Identifier
TIGR04345

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

6 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cre12.g503650.t1.2 A8IJL8 PAC:30792673 Chlamydomonas reinhardtii 308  
Cre08.g380000.t1.2 A0A2K3DHZ2 PAC:30773887 Chlamydomonas reinhardtii 917  
Cz12g19090.t1 PAC:38239908 Chromochloris zofingiensis 919  
Zosma07g00390 PAC:50101707 Zostera marina 3291  
Vocar.0042s0038.1.p PAC:32892109 Volvox carteri 932  
Vocar.0006s0181.1.p PAC:32893872 Volvox carteri 311  

3 Publications

First Author Title Year Journal Volume Pages PubMed ID
            21247153
            11420105
            17119635