Protein Domain : IPR002714

Type:  Family Name:  Von Hippel-Lindau tumour suppressor protein
Description:  VHL (von Hippel-Lindau disease tumor suppressor) is a component of the VCB (VHL-Elongin BC-CUL2) complex; this complex acts as a ubiquitin-ligase E3 and directs proteasome-dependent degradation of targeted proteins []. Human VHL has been demonstrated to form a ternary complex with elonginB and elonginC proteins []. This complex binds Cul2, which then is involved in regulation of vascular endothelial growth factor mRNA. VHL appears to act as the target recruitment subunit in the E3 ubiquitin ligase complex and recruit hydroxylated hypoxia-inducible factor (HIF) under normal oxygen conditions []. VHL is also involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases []. Like human VHL, Drosophila VHL complex containing Cul-2, Rbx1, Elongins B and C, exhibits E3 ubiquitin ligase activity []. However, proteins in this entry also include Von Hippel-Lindau-like (VHLL) protein from human. It may has little or no E3 ubiquitin ligase activity as it lacks the alpha domain required for nucleating the multiprotein E3 ubiquitin ligase complex []. Short Name:  VHL
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR15160:SF0

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cre12.g556500.t1.2 A0A2K3D5T1 PAC:30793217 Chlamydomonas reinhardtii 755  
Cre16.g663700.t1.1 A0A2K3CTQ3 PAC:30777011 Chlamydomonas reinhardtii 508  
Cre03.g177450.t1.1 A0A2K3DXJ2 PAC:30787270 Chlamydomonas reinhardtii 456  
Vocar.0015s0190.1.p PAC:32899083 Volvox carteri 507  

6 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10205047
            12050673
            9122164
            11006129
            10944113
            14757845