Protein Domain : IPR011022

Type:  Domain Name:  Arrestin C-terminal-like domain
Description:  Arrestins comprise a family of closely-related proteins. In addition to the inactivation of G protein-coupled receptors, arrestins have been implicated in the endocytosis of receptors and cross talk with other signalling pathways. S-Arrestin (retinal S-antigen) is a major protein of the retinal rod outer segments. It interacts with photo-activated phosphorylated rhodopsin, inhibiting or 'arresting' its ability to interact with transducin []. Beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X) [], which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction [, , ].The crystal structure of bovine retinal arrestin comprises two domains of antiparallel beta-sheets connected through a hinge region and one short alpha-helix on the back of the amino-terminal fold []. This C-terminal domain consists of an immunoglobulin-like beta-sandwich structure. This domain is found in arrestins and in other proteins including arrestin domain-containing proteins, protein ROD1 [] and ROG3 [] and thioredoxin-interacting protein []. Short Name:  Arrestin_C-like
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1 Child Features

DB identifier Type Name
IPR014752 Domain Arrestin, C-terminal

0 Contains

2 Cross Referencess

Identifier
PF02752
SM01017

0 Found In

0 GO Annotation

0 Ontology Annotations

0 Parent Features

7 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cre14.g624800.t1.2 A0A2K3CY81 PAC:30776096 Chlamydomonas reinhardtii 494  
Dusal.0018s00025.1.p PAC:33187070 Dunaliella salina 398  
Dusal.0792s00008.1.p PAC:33202153 Dunaliella salina 270  
Dusal.0801s00003.1.p PAC:33200631 Dunaliella salina 388  
Dusal.1503s00001.1.p PAC:33201540 Dunaliella salina 390  
Cz03g00210.t1 PAC:38241440 Chromochloris zofingiensis 373  
Cz15g13160.t1 PAC:38234633 Chromochloris zofingiensis 445  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            8452755
            15335861
            7720881
            1517224
            9495348
            2158671
            8621680
            12163175
            17603038