Type: | Domain | Name: | Arfaptin homology (AH) domain |
Description: | The arfaptin homology (AH) domain is a protein domain found in a range of proteins, including arfaptins, protein kinase C-binding protein PICK1 [] and mammalian 69 kDa islet cell autoantigen (ICA69) []. The AH domain of arfaptin has been shown to dimerise and to bind Arf and Rho family GTPases [, ], including ARF1, a small GTPase involved in vesicle budding at the Golgi complex and immature secretory granules.The AH domain consists of three alpha-helices arranged as an extended antiparallel alpha-helical bundle. Two arfaptin AH domains associate to form a highly elongated, crescent-shaped dimer [, ]. | Short Name: | AH_dom |