Protein Domain : IPR011620

Type:  Domain Name:  Signal transduction histidine kinase, 5TM receptor LytS, transmembrane region
Description:  Signal transducing histidine kinases are the key elements in two-component signal transduction systems, which control complex processes such as the initiation of development in microorganisms [, ]. Examples of histidine kinases are EnvZ, which plays a central role in osmoregulation [], and CheA, which plays a central role in the chemotaxis system []. Histidine kinases usually have an N-terminal ligand-binding domain and a C-terminal kinase domain, but other domains may also be present. The kinase domain is responsible for the autophosphorylation of the histidine with ATP, the phosphotransfer from the kinase to an aspartate of the response regulator, and (with bifunctional enzymes) the phosphotransfer from aspartyl phosphate back to ADP or to water []. The kinase core has a unique fold, distinct from that of the Ser/Thr/Tyr kinase superfamily. HKs can be roughly divided into two classes: orthodox and hybrid kinases [, ]. Most orthodox HKs, typified by the Escherichia coliEnvZ protein, function as periplasmic membrane receptors and have a signal peptide and transmembrane segment(s) that separate the protein into a periplasmic N-terminal sensing domain and a highly conserved cytoplasmic C-terminal kinase core. Members of this family, however, have an integral membrane sensor domain. Not all orthodox kinases are membrane bound, e.g., the nitrogen regulatory kinase NtrB (GlnL) is a soluble cytoplasmic HK []. Hybrid kinases contain multiple phosphodonor and phosphoacceptor sites and use multi-step phospho-relay schemes instead of promoting a single phosphoryl transfer. In addition to the sensor domain and kinase core, they contain a CheY-like receiver domain and a His-containing phosphotransfer (HPt) domain.This entry represents the transmembrane region of the 5TM-Lyt (5TM Receptors of the LytS-YhcK type) histidine kinase []. The two-component regulatory system LytS/LytT probably regulates genes involved in cell wall metabolism. Short Name:  Sig_transdc_His_kinase_LytS_TM
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0 Child Features

0 Contains

1 Cross References

Identifier
PF07694

0 Found In

5 GO Annotations

GO Term Gene Name
GO:0000155 IPR011620
GO:0004673 IPR011620
GO:0000160 IPR011620
GO:0071555 IPR011620
GO:0016021 IPR011620

5 Ontology Annotations

GO Term Gene Name
GO:0000155 IPR011620
GO:0004673 IPR011620
GO:0000160 IPR011620
GO:0071555 IPR011620
GO:0016021 IPR011620

0 Parent Features

1 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Thupl.29072506s0001.1.p PAC:44960846 Thuja plicata 133  

9 Publications

First Author Title Year Journal Volume Pages PubMed ID
            10966457
            9989504
            8868347
            10426948
            11145881
            11406410
            8029829
            1482126
            12914674