Protein Domain : IPR022941

Type:  Family Name:  Signal recognition particle, SRP54 subunit
Description:  This entry represents the SRP54 subunit of the signal recognition particle protein translocation system.The signal recognition particle (SRP) is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough endoplasmic reticulum (RER) membrane in eukaryotes, or to the plasma membrane in prokaryotes [, ]. SRP recognises the signal sequence of the nascent polypeptide on the ribosome. In eukaryotes this retards its elongation until SRP docks the ribosome-polypeptide complex to the RER membrane via the SR receptor []. Eukaryotic SRP consists of six polypeptides (SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72) and a single 300 nucleotide 7S RNA molecule. The RNA component catalyses the interaction of SRP with its SR receptor []. In higher eukaryotes, the SRP complex consists of the Alu domain and the S domain linked by the SRP RNA. The Alu domain consists of a heterodimer of SRP9 and SRP14 bound to the 5' and 3' terminal sequences of SRP RNA. This domain is necessary for retarding the elongation of the nascent polypeptide chain, which gives SRP time to dock the ribosome-polypeptide complex to the RER membrane. In archaea, the SRP complex contains 7S RNA like its eukaryotic counterpart, yet only includes two of the six protein subunits found in the eukarytic complex: SRP19 and SRP54 [].The bacterial homologues of the SRP54 protein and SRP RNA are Ffh and 4.5S RNA. They comprise a minimal bacterial SRP that can target ribosome-nascent chain complexes to the plasma membrane via interaction with FtsY, the bacterial homologue of the SRP receptor [, ]. Short Name:  SRP54
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2 Child Features

DB identifier Type Name
IPR004780 Family Signal recognition particle protein Ffh
IPR006325 Family Signal recognition particle, SRP54 subunit, eukaryotic

0 Contains

1 Cross References

Identifier
MF_00306

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003924 IPR022941
GO:0005525 IPR022941
GO:0006614 IPR022941
GO:0048500 IPR022941

4 Ontology Annotations

GO Term Gene Name
GO:0003924 IPR022941
GO:0005525 IPR022941
GO:0006614 IPR022941
GO:0048500 IPR022941

0 Parent Features

5 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Zosma01g03810 A0A0K9NX30 PAC:50092720 Zostera marina 640  
Zosma01g12670 PAC:50091539 Zostera marina 500  
Zosma01g33780 PAC:50091283 Zostera marina 570  
Zosma05g33990 A0A0K9NVB3 PAC:50105414 Zostera marina 369  
Zosma07g00410 PAC:50102023 Zostera marina 1463  

7 Publications

First Author Title Year Journal Volume Pages PubMed ID
            16469117
            17622352
            17507650
            12364595
            12605305
            9799502
            10656787