Protein Domain : IPR027132

Type:  Family Name:  Structural maintenance of chromosomes protein 6
Description:  SMC6 is a core component of the SMC5-SMC6 complex [, ], a complex involved in repair of DNA double-strand breaks by homologous recombination []. In humans, the complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks []. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) []. Short Name:  SMC6
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0 Child Features

0 Contains

1 Cross References

Identifier
PTHR19306:SF2

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0000724 IPR027132
GO:0006281 IPR027132
GO:0030915 IPR027132

3 Ontology Annotations

GO Term Gene Name
GO:0000724 IPR027132
GO:0006281 IPR027132
GO:0030915 IPR027132

0 Parent Features

2 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Zosma02g15420 PAC:50089733 Zostera marina 557  
Zosma02g15410 PAC:50089949 Zostera marina 1043  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            15738391
            16810316
            17589526
            15010319
            18086888