Protein Domain : IPR013059

Type:  Family Name:  Tryptophan/tyrosine transporter
Description:  Amino acid permeases are integral membrane proteins involved in the transport of amino acids into the cell. A number of such proteins have been found to beevolutionary related [, , ].Aromatic amino acids are concentrated in the cytoplasm of Escherichia coliby 4 distinct transport systems: a general aromatic amino acid permease, and aspecific permease for each of the 3 types (Phe, Tyr and Trp) []. It has been shown [] that some permeases in E. coli and related bacteria are evolutionary related.These permeases are proteins of about 400 to 420 amino acids and are located in the cytoplasmic membrane and, like bacterial sugar/cation transporters, are thought to contain 12 transmembrane (TM) regions [] - hydropathy analysis, however, is inconclusive, suggesting thepossibility of 10 to 12 membrane-spanning domains []. The best conserved domain is a stretch of 20 residues which seems to be located in a cytoplasmic loop between thefirst and second transmembrane region.This family is specific for aromatic amino acid transporters and includes the tyrosine permease, TyrP (), and the tryptophan transporters TnaB () and Mtr () of E. coli. Short Name:  Trp_tyr_transpt
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0 Child Features

1 Contains

DB identifier Type Name
IPR013061 Conserved_site Tryptophan/tryrosine permease, conserved site

1 Cross References

Identifier
TIGR00837

0 Found In

3 GO Annotations

GO Term Gene Name
GO:0015173 IPR013059
GO:0015801 IPR013059
GO:0005887 IPR013059

3 Ontology Annotations

GO Term Gene Name
GO:0015173 IPR013059
GO:0015801 IPR013059
GO:0005887 IPR013059

1 Parent Features

DB identifier Type Name
IPR002091 Family Aromatic amino acid permease

4 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Zosma02g19000 A0A0K9NLU8 PAC:50088754 Zostera marina 477  
Zosma02g24420 PAC:50088789 Zostera marina 424  
Zosma05g22350 A0A0K9PRB7 PAC:50105328 Zostera marina 482  
Zosma06g26960 A0A0K9PS83 PAC:50100355 Zostera marina 444  

5 Publications

First Author Title Year Journal Volume Pages PubMed ID
            2687114
            1987112
            2022620
            3146645
            8382989