| Type: | Family | Name: | Lymphotoxin-beta |
| Description: | Cytokines can be grouped into a family on the basis of sequence, functional and structural similarities [, , ]. Tumor necrosis factor (TNF) (also known as TNF-alpha or cachectin) is a monocyte-derived cytotoxin that has been implicated in tumour regression, septic shock and cachexia [, ]. The protein is synthesised as a prohormone with an unusually long and atypical signal sequence, which is absent from the mature secreted cytokine []. A short hydrophobic stretch of amino acids serves to anchor the prohormone in lipid bilayers []. Both the mature protein and a partially-processed form of the hormone are secreted after cleavage of the propeptide [].There are a number of different families of TNF, but all these cytokines seem to form homotrimeric (or heterotrimeric in the case of LT-alpha/beta) complexes that are recognised by their specific receptors. Lymphotoxin-alpha (LT-alpha or TNF-beta) and lymphotoxin-beta (LT-beta) are related cytokines produced by lymphocytes. The proteins are cytotoxic for awide range of tumour cells in vitroand in vivo. This entry represents Tumour necrosis factor C (TNFC or LT-beta). The gene isfound next to the TNF-LT locus in the major histocompatibility complex (MHC), a region of the MHC with possible linkage to autoimmune disease []. It is possible that a surface LT-alpha/LT-beta complex may have a specific role in immune regulation distinct from the functions ascribed to TNF []. | Short Name: | TNF_C |
| GO Term | Gene Name |
|---|---|
| GO:0005164 | IPR002961 |
| GO:0006955 | IPR002961 |
| GO:0016020 | IPR002961 |
| DB identifier | UniProt Accession | Secondary Identifier | Organism Name | Length |
|---|---|---|---|---|
| Urofu.7G220700.1.p | PAC:50117962 | Urochloa fusca |
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