Protein Domain : IPR009105

Type:  Domain Name:  Colicin E3-like ribonuclease domain
Description:  Colicins are plasmid-encoded protein antibiotics, or bacteriocins, produced by strains of Escherichia colithat kill closely related bacteria. Colicins are classified according to the cell-surface receptor they bind to, colicin E3 binding to the BtuB receptor involved in vitamin B12 uptake. The lethal action of colicin E3 arises from its ability to inactivate the ribosome by site-specific RNase cleavage of the 16S ribosomal RNA, which is carried out by the catalytic, or ribonuclease domain. Colicin E3 is comprised of three domains, each domain being involved in a different stage of infection: receptor binding, translocation and cytotoxicity. Colicin E3 is a Y-shaped molecule with the receptor-binding middle domain forming the stalk, the N-terminal translocation domain forming the two globular heads, and the C-terminal catalytic domain forming the two globular arms. To neutralise the toxic effects of colicin E3, the host cell produces an immunity protein, which binds to the C-terminal end of the ribonuclease domain and effectively suppresses its activity.This entry represents the ribonuclease domain (also called catalytic or cytotoxic domain) found in various colicins. This domain confers cytotoxic activity to proteins, enabling the formation of nucleolytic breaks in 16S ribosomal RNA. The structure of the domain reveals a highly twisted central beta-sheet elaborated with a short N-terminal alpha-helix [, ]. Short Name:  Colicin_E3_ribonuclease
Paste the following link

0 Child Features

0 Contains

3 Cross Referencess

Identifier
PF09000
G3DSA:3.10.380.10
SSF63840

0 Found In

4 GO Annotations

GO Term Gene Name
GO:0003723 IPR009105
GO:0016788 IPR009105
GO:0043022 IPR009105
GO:0009405 IPR009105

4 Ontology Annotations

GO Term Gene Name
GO:0003723 IPR009105
GO:0016788 IPR009105
GO:0043022 IPR009105
GO:0009405 IPR009105

0 Parent Features

146 Proteins

DB identifier UniProt Accession Secondary Identifier Organism Name Length
Cucsa.046600.1 PAC:16953550 Cucumis sativus 483  
Glyma.06G285800.3.p K7KXY5 PAC:30552301 Glycine max 478  
Glyma.06G285800.2.p A0A0R0JTQ5 PAC:30552302 Glycine max 391  
Glyma.06G285800.1.p K7KXY5 PAC:30552300 Glycine max 478  
Glyma.12G120100.4.p K7LUC5 PAC:30547463 Glycine max 479  
Glyma.12G120100.1.p K7LUC5 PAC:30547460 Glycine max 479  
Glyma.12G120100.3.p K7LUC5 PAC:30547461 Glycine max 479  
Glyma.12G120100.2.p K7LUC5 PAC:30547462 Glycine max 479  
Brara.I01163.1.p A0A397XTG1 PAC:30644092 Brassica rapa FPsc 211  
Medtr5g070670.1 G7KE77 PAC:31087144 Medicago truncatula 849  
SapurV1A.1321s0020.1.p PAC:31441889 Salix purpurea 656  
Manes.12G092900.1.p A0A251JN44 PAC:32344656 Manihot esculenta 470  
Manes.12G092900.2.p A0A251JN44 PAC:32344657 Manihot esculenta 470  
Pahal.I02289.1 A0A2S3IJH0 PAC:32508774 Panicum hallii 427  
Sphfalx0202s0025.1.p PAC:32627875 Sphagnum fallax 309  
Mapoly0237s0006.1.p A0A2R6VZM8 PAC:33005457 Marchantia polymorpha 249  
Aco029942.1 PAC:33029787 Ananas comosus 191  
Zosma192g00200.1 A0A0K9PRJ1 PAC:33171279 Zostera marina 482  
Dusal.0540s00009.1.p PAC:33202821 Dunaliella salina 125  
Brdisv1BdTR7a1000599m.p PAC:33341876 Brachypodium distachyon BdTR7a 156  
Brdisv1Tek-41028098m.p PAC:33499752 Brachypodium distachyon Tek-4 156  
Brdisv1ABR9_r1000556m.p PAC:33529585 Brachypodium distachyon ABR9 156  
Brdisv1BdTR8i1043047m.p PAC:34242062 Brachypodium distachyon BdTR8i 251  
Tp57577_TGAC_v2_mRNA7068 PAC:35958532 Trifolium pratense 639  
DCAR_015896 PAC:36079053 Daucus carota 427  
Phvul.011G115600.4.p V7AHH0 PAC:37156224 Phaseolus vulgaris 450  
Phvul.011G115600.2.p PAC:37156222 Phaseolus vulgaris 455  
Phvul.011G115600.1.p V7AHH0 PAC:37156226 Phaseolus vulgaris 450  
Phvul.011G115600.3.p PAC:37156223 Phaseolus vulgaris 455  
Phvul.011G115600.5.p V7AHH0 PAC:37156225 Phaseolus vulgaris 450  

2 Publications

First Author Title Year Journal Volume Pages PubMed ID
            11741540
            10986462